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• W2073075100 abstract "<h2>Abstract</h2> Over the last decades, the medical world has advanced dramatically in the understanding of fracture repair. The three components needed for fracture healing are osteoconduction, osteoinduction and osteogenesis. With newly designed scaffolds, <i>ex vivo</i> produced growth factors and isolated stem cells, most of the challenges of critical size bone defects have been resolved <i>in vitro</i>, and in some cases in animal models as well. However, there are still challenges needed to be overcome before these technologies can be fully converted from the bench to the bedside. These technological and biological advancements need to be converted to mass production of affordable products that can be used in every part of the world. Vascularity, full substation of scaffolds by native bone, and bio-safety are the three most critical steps to be challenged before reaching the clinical setting." @default.
• W2073075100 created "2016-06-24" @default.
• W2073075100 creator A5057267378 @default.
• W2073075100 creator A5072999739 @default.
• W2073075100 date "2011-06-01" @default.
• W2073075100 modified "2023-09-29" @default.
• W2073075100 title "Tissue engineering approaches for bone repair: Concepts and evidence" @default.
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• W2073075100 doi "https://doi.org/10.1016/j.injury.2011.03.029" @default.
• W2073075100 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21489529" @default.
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