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- W2073075211 abstract "The ability of Schistosoma mansoni to generate energy through aerobic metabolic processes was examined in adult parasites in vitro. Parasite catabolism of radiolabeled glucose, glutamine, and other amino acids to CO2 and Krebs cycle intermediates was measured under a variety of incubation conditions. l-Glutamine was metabolized to CO2 via the intermediates glutamate, α-ketoglutaramate, and α-ketoglutarate in worms incubated in a balanced salts solution containing this amino acid as the only organic constituent. Of the other amino acids tested, CO2 production was detected from l-glutamate and l-asparagine. The catabolism of l-glutamine to CO2 was reduced by the respiratory inhibitor antimycin A. The motility of schistosomes in culture was maintained for at least 24 hr when l-glutamine was the only carbon source available to the worms. Under these conditions, motility was reduced when parasites were exposed to a respiratory inhibitor such as KCN, antimycin A, rotenone, or oligomycin, but it was completely restored by the addition of glucose to the medium. These results suggest that while the schistosome is capable of limited aerobic energy-generating processes under certain conditions, survival is not contingent upon these processes in the presence of glucose." @default.
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- W2073075211 date "1989-07-01" @default.
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- W2073075211 title "Glutamine- vs glucose-supported motor activity in Schistosoma mansoni: Physiological relevance of aerobic metabolism" @default.
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- W2073075211 doi "https://doi.org/10.1016/0014-4894(89)90170-7" @default.
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