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- W2073076229 abstract "The aim of the present study was to evaluate the immunohistochemical expression of proliferation, apoptosis, and oncogene markers in the epithelial lining of odontogenic cysts (OC). Eighteen cases of OC were retrieved from our files. Six cases of dentigerous cyst (DC), 7 cases of odontogenic keratocyst (OKC), 4 cases of periapical cyst (PAC), and 1 case of glandular odontogenic cyst (GOC) were selected. Three-μm sections were obtained for immunohistochemical technique. PCNA (1:200), ki-67 (1:50), p53 (1:50), and bcl2 (1:25) were used as primary antibodies. Our results showed that PCNA was expressed in 4/6 cases (66.67%) of DC, ki67 was expressed in 3/6 cases (50%), and bcl2 and p53 in 2/6 cases (33.33%). Additionally, PCNA was positive in 4/7 cases of OKC (57.16%), and the rest of the markers were uniformly expressed in 1/7 cases (14.28%). However, 2/4 (50%) of the PAC cases were immunopositive for PCNA, and the rest of the cases expressed only bcl2. The only case of GOC expressed similar positivity for all markers. We may conclude from the present study that PCNA was the most common proliferation marker expressed in all OC. DC and OKC expressed all markers, in contrast to PAC, which exhibited positivity for only PCNA and bcl2, probably owing to its inflammatory pathogenesis. The only case of GOC showed a strong expression of the 4 markers along the epithelial lining and within the mucous cells, evidencing the proliferative activity and the potential for neoplastic transformation of this entity." @default.
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- W2073076229 date "2005-08-01" @default.
- W2073076229 modified "2023-10-18" @default.
- W2073076229 title "Expression of PCNA, KI-67, BCL2, and P53 in Odontogenic Cysts" @default.
- W2073076229 doi "https://doi.org/10.1016/j.tripleo.2005.05.037" @default.
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