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- W2073076454 abstract "The antiarrhythmic activity of a new β-adrenergic blocking agent, 6-(2-hydroxy-3-isopropylaminopropyloxy)-benzothiazole succinate (KF-577), was compared with that of propranolol. KF-577 antagonized ouabain-induced arrhythmias in normal and bilaterally vagotomized guinea pigs; its antagonistic activity was equal to that of propranolol. Reserpinization greatly reduced ouabain intoxication and neither of the two β-blockers produced further reduction. Aconitine-induced arrhythmias in rats were not antagonized by the two agents. In intact guinea pigs, the reduction of ouabain intoxication by both β-blockers could not exceed that produced by simultaneous infusion of KCl, and vice versa. In isolated guinea pig atria, propranolol was about 10 times more effective than KF-577 in reducing the ouabain intoxication. The antiarrhythmic activity of KF-577 paralleled its β-blocking activity in the isolated preparations but not in the intact animals." @default.
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- W2073076454 date "1976-11-01" @default.
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- W2073076454 title "Antiarrhythmic action of a new β-adrenergic blocking agent, 6-(2-hydroxy-3-isopropylaminopropyloxy)-benzothiazole succinate (KF-577), compared with that of propranolol" @default.
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- W2073076454 doi "https://doi.org/10.1016/0014-2999(76)90364-2" @default.
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