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- W2073077068 abstract "As a part of our studies on the folding of glycoproteins in the ER, we analyzed the fate of viral glycoproteins that have misfolded either spontaneously or through inhibition of N-linked glycosylation. Newly synthesized Semliki Forest virus spike glycoproteins E1 and p62 and influenza hemagglutinin were studied in infected and transfected tissue culture cells. Misfolded proteins aggregated in less than 1 min after release from polysomes and aberrant interchain disulfide bonds were formed immediately. When more than one protein was misfolded, mixed aggregates were generated. This indicated that the formation of complexes was nonspecific, random, and not restricted to products from single polysomes. The size of the aggregates varied from small oligomers to complexes of several million daltons. BiP was associated noncovalently with the aggregates and with some of the nonaggregated products. We conclude that aggregation reflects the poor solubility of incompletely folded polypeptide chains." @default.
- W2073077068 created "2016-06-24" @default.
- W2073077068 creator A5033110590 @default.
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- W2073077068 date "1992-05-01" @default.
- W2073077068 modified "2023-10-14" @default.
- W2073077068 title "Misfolding and aggregation of newly synthesized proteins in the endoplasmic reticulum." @default.
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- W2073077068 doi "https://doi.org/10.1083/jcb.117.3.505" @default.
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