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• W2073080330 endingPage "12185" @default.
• W2073080330 startingPage "12171" @default.
• W2073080330 abstract "After birth, stem cells in the subventricular zone (SVZ) generate neuroblasts that migrate along the rostral migratory stream (RMS) to become interneurons in the olfactory bulb (OB). This migration is a fundamental event controlling the proper integration of new neurons in a pre-existing synaptic network. Many regulators of neuroblast migration have been identified; however, still very little is known about the intracellular molecular mechanisms controlling this process. Here, we show that the actin-bundling protein fascin is highly upregulated in mouse SVZ-derived migratory neuroblasts. Fascin-1ko mice display an abnormal RMS and a smaller OB. Bromodeoxyuridine labeling experiments show that lack of fascin significantly impairs neuroblast migration, but does not appear to affect cell proliferation. Moreover, fascin depletion substantially alters the polarized morphology of rat neuroblasts. Protein kinase C (PKC)-dependent phosphorylation of fascin on Ser39 regulates its actin-bundling activity. In vivo postnatal electroporation of phosphomimetic (S39D) or nonphosphorylatable (S39A) fascin variants followed by time-lapse imaging of brain slices demonstrates that the phospho-dependent modulation of fascin activity ensures efficient neuroblast migration. Finally, fluorescence lifetime imaging microscopy studies in rat neuroblasts reveal that the interaction between fascin and PKC can be modulated by cannabinoid signaling, which controls neuroblast migration in vivo. We conclude that fascin, whose upregulation appears to mark the transition to the migratory neuroblast stage, is a crucial regulator of neuroblast motility. We propose that a tightly regulated phospho/dephospho-fascin cycle modulated by extracellular signals is required for the polarized morphology and migration in neuroblasts, thus contributing to efficient neurogenesis." @default.
• W2073080330 created "2016-06-24" @default.
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• W2073080330 date "2013-07-24" @default.
• W2073080330 modified "2023-10-16" @default.
• W2073080330 title "Fascin Regulates the Migration of Subventricular Zone-Derived Neuroblasts in the Postnatal Brain" @default.
• W2073080330 cites W1548959511 @default.
• W2073080330 cites W1575310353 @default.
• W2073080330 cites W1905021482 @default.
• W2073080330 cites W1965310536 @default.
• W2073080330 cites W1965959102 @default.
• W2073080330 cites W1966765683 @default.
• W2073080330 cites W1967972793 @default.
• W2073080330 cites W1969429012 @default.
• W2073080330 cites W1971156182 @default.
• W2073080330 cites W1971526742 @default.
• W2073080330 cites W1974666951 @default.
• W2073080330 cites W1979695022 @default.
• W2073080330 cites W1980116545 @default.
• W2073080330 cites W1980824787 @default.
• W2073080330 cites W1981690123 @default.
• W2073080330 cites W1982406453 @default.
• W2073080330 cites W1992920115 @default.
• W2073080330 cites W1995557164 @default.
• W2073080330 cites W2001674723 @default.
• W2073080330 cites W2004487272 @default.
• W2073080330 cites W2004593278 @default.
• W2073080330 cites W2005007296 @default.
• W2073080330 cites W2005981572 @default.
• W2073080330 cites W2007242343 @default.
• W2073080330 cites W2009647598 @default.
• W2073080330 cites W2012253237 @default.
• W2073080330 cites W2012305618 @default.
• W2073080330 cites W2013009055 @default.
• W2073080330 cites W2014803841 @default.
• W2073080330 cites W2015829020 @default.
• W2073080330 cites W2019542843 @default.
• W2073080330 cites W2019903295 @default.
• W2073080330 cites W2032619723 @default.
• W2073080330 cites W2035250926 @default.
• W2073080330 cites W2035918801 @default.
• W2073080330 cites W2046114399 @default.
• W2073080330 cites W2048525391 @default.
• W2073080330 cites W2051153598 @default.
• W2073080330 cites W2052231225 @default.
• W2073080330 cites W2052316576 @default.
• W2073080330 cites W2057021679 @default.
• W2073080330 cites W2060854925 @default.
• W2073080330 cites W2061847345 @default.
• W2073080330 cites W2063377436 @default.
• W2073080330 cites W2064759994 @default.
• W2073080330 cites W2065754676 @default.
• W2073080330 cites W2065992716 @default.
• W2073080330 cites W2067404934 @default.
• W2073080330 cites W2068445328 @default.
• W2073080330 cites W2069671270 @default.
• W2073080330 cites W2074478109 @default.
• W2073080330 cites W2075127308 @default.
• W2073080330 cites W2085274174 @default.
• W2073080330 cites W2088144746 @default.
• W2073080330 cites W2090355988 @default.
• W2073080330 cites W2101565835 @default.
• W2073080330 cites W2104520647 @default.
• W2073080330 cites W2105619265 @default.
• W2073080330 cites W2105636240 @default.
• W2073080330 cites W2110416410 @default.
• W2073080330 cites W2111897479 @default.
• W2073080330 cites W2114400985 @default.
• W2073080330 cites W2121588102 @default.
• W2073080330 cites W2136841975 @default.
• W2073080330 cites W2138028202 @default.
• W2073080330 cites W2139486959 @default.
• W2073080330 cites W2141640447 @default.
• W2073080330 cites W2146548883 @default.
• W2073080330 cites W2154477609 @default.
• W2073080330 cites W2155287512 @default.
• W2073080330 cites W2155533668 @default.
• W2073080330 cites W2156993967 @default.
• W2073080330 cites W2160287079 @default.
• W2073080330 cites W2161042020 @default.
• W2073080330 cites W2165867905 @default.
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• W2073080330 doi "https://doi.org/10.1523/jneurosci.0653-13.2013" @default.
• W2073080330 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3721833" @default.
• W2073080330 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23884926" @default.
• W2073080330 hasPublicationYear "2013" @default.
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• W2073080330 citedByCount "43" @default.

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