Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073090407> ?p ?o ?g. }
- W2073090407 endingPage "661" @default.
- W2073090407 startingPage "652" @default.
- W2073090407 abstract "This review summarizes new insights into the role of the actin cytoskeleton in exocytosis and compensatory membrane retrieval from mammalian regulated secretory cells. Data from our lab and others now indicate that the actin cytoskeleton is involved in exocytosis both as a negative regulator of membrane fusion under resting conditions and as a facilitator of movement of secretory granules to their site of fusion with the apical plasmalemma. Coating of docked secretory granules with actin filaments correlates with the dissociation of secretory-granule-associated rab3D, pointing out a novel role for rab proteins in modulating the actin cytoskeleton during regulated exocytosis. Compensatory membrane retrieval following regulated exocytosis is also critically dependent on the actin cytoskeleton both in initiating the formation of clathrin-coated retrieval vesicles and subsequent trafficking back into the cell. We propose that insertion of secretory granule membrane into the plasmalemma initiates a trigger for membrane retrieval, possibly by exposing sites where proteins involved in compensatory membrane retrieval are assembled. The results summarized in this review were derived primarily from investigations on the pancreatic acinar cell, an old friend who is providing modern wisdom not attainable in other simpler systems." @default.
- W2073090407 created "2016-06-24" @default.
- W2073090407 creator A5017838878 @default.
- W2073090407 creator A5052068656 @default.
- W2073090407 creator A5071555653 @default.
- W2073090407 date "1999-12-01" @default.
- W2073090407 modified "2023-09-26" @default.
- W2073090407 title "Role of Actin in Regulated Exocytosis and Compensatory Membrane Retrieval: Insights from an Old Acquaintance" @default.
- W2073090407 cites W1494464161 @default.
- W2073090407 cites W1524475817 @default.
- W2073090407 cites W1561770236 @default.
- W2073090407 cites W1564650596 @default.
- W2073090407 cites W1574831557 @default.
- W2073090407 cites W1576786159 @default.
- W2073090407 cites W1821459756 @default.
- W2073090407 cites W1913497294 @default.
- W2073090407 cites W1936931129 @default.
- W2073090407 cites W1970654974 @default.
- W2073090407 cites W1978627586 @default.
- W2073090407 cites W1978916680 @default.
- W2073090407 cites W1983737411 @default.
- W2073090407 cites W1986160135 @default.
- W2073090407 cites W1987195453 @default.
- W2073090407 cites W1988564507 @default.
- W2073090407 cites W1994445058 @default.
- W2073090407 cites W1996328637 @default.
- W2073090407 cites W1996862455 @default.
- W2073090407 cites W1999679029 @default.
- W2073090407 cites W1999922223 @default.
- W2073090407 cites W2000364427 @default.
- W2073090407 cites W2004194377 @default.
- W2073090407 cites W2006204413 @default.
- W2073090407 cites W2013713760 @default.
- W2073090407 cites W2015011519 @default.
- W2073090407 cites W2015295443 @default.
- W2073090407 cites W2015799458 @default.
- W2073090407 cites W2016417523 @default.
- W2073090407 cites W2022447364 @default.
- W2073090407 cites W2024383929 @default.
- W2073090407 cites W2025262639 @default.
- W2073090407 cites W2025929812 @default.
- W2073090407 cites W2028069387 @default.
- W2073090407 cites W2030498394 @default.
- W2073090407 cites W2033067408 @default.
- W2073090407 cites W2035873091 @default.
- W2073090407 cites W2036295008 @default.
- W2073090407 cites W2036821622 @default.
- W2073090407 cites W2037425715 @default.
- W2073090407 cites W2038328161 @default.
- W2073090407 cites W2041669650 @default.
- W2073090407 cites W2042358229 @default.
- W2073090407 cites W2044496080 @default.
- W2073090407 cites W2046801806 @default.
- W2073090407 cites W2047302810 @default.
- W2073090407 cites W2050669001 @default.
- W2073090407 cites W2051275728 @default.
- W2073090407 cites W2051842061 @default.
- W2073090407 cites W2052110964 @default.
- W2073090407 cites W2054922048 @default.
- W2073090407 cites W2059401109 @default.
- W2073090407 cites W2059717849 @default.
- W2073090407 cites W2061936950 @default.
- W2073090407 cites W2064951453 @default.
- W2073090407 cites W2070418818 @default.
- W2073090407 cites W2076364749 @default.
- W2073090407 cites W2082426787 @default.
- W2073090407 cites W2085680244 @default.
- W2073090407 cites W2085871244 @default.
- W2073090407 cites W2089617170 @default.
- W2073090407 cites W2092229320 @default.
- W2073090407 cites W2098349937 @default.
- W2073090407 cites W2099942500 @default.
- W2073090407 cites W2105630800 @default.
- W2073090407 cites W2112652451 @default.
- W2073090407 cites W2114356820 @default.
- W2073090407 cites W2125144482 @default.
- W2073090407 cites W2126730087 @default.
- W2073090407 cites W2129090701 @default.
- W2073090407 cites W2130888342 @default.
- W2073090407 cites W2131411591 @default.
- W2073090407 cites W2131653836 @default.
- W2073090407 cites W2147556035 @default.
- W2073090407 cites W2152915799 @default.
- W2073090407 cites W2153763976 @default.
- W2073090407 cites W2154625078 @default.
- W2073090407 cites W2158299745 @default.
- W2073090407 cites W2163751558 @default.
- W2073090407 cites W2171403233 @default.
- W2073090407 cites W2172095199 @default.
- W2073090407 cites W2176719787 @default.
- W2073090407 cites W2181557843 @default.
- W2073090407 cites W2287728217 @default.
- W2073090407 doi "https://doi.org/10.1006/bbrc.1999.1883" @default.
- W2073090407 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10603303" @default.
- W2073090407 hasPublicationYear "1999" @default.
- W2073090407 type Work @default.
- W2073090407 sameAs 2073090407 @default.
- W2073090407 citedByCount "84" @default.