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- W2073103657 abstract "Progenitors that express NG2-proteoglycan are the predominant self-renewing cells within the CNS. NG2 progenitors replenish oligodendrocyte populations within the intact stem cell niche, and cycling NG2 cells are among the first cells to react to CNS insults. We investigated the role of NG2 progenitors after spinal cord injury and how bone morphogen protein signals remodel the progressive postinjury (PI) niche. Progeny labeled by an NG2-specific reporter virus undergo a coordinated shift in differentiation profile. NG2 progeny born 24 h PI produce scar-forming astrocytes and transient populations of novel phagocytic astrocytes shown to contain denatured myelin within cathepsin-D-labeled endosomes, but NG2 progenitors born 7 d PI differentiate into oligodendrocytes and express myelin on processes that wrap axons. Analysis of spinal cord mRNA shows a temporal shift in the niche transcriptome of ligands that affect PI remodeling and direct progenitor differentiation. We conclude that NG2 progeny are diverse lineages that obey progressive cues after trauma to replenish the injured niche." @default.
- W2073103657 created "2016-06-24" @default.
- W2073103657 creator A5016118703 @default.
- W2073103657 creator A5031325248 @default.
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- W2073103657 date "2009-05-20" @default.
- W2073103657 modified "2023-10-02" @default.
- W2073103657 title "Postinjury Niches Induce Temporal Shifts in Progenitor Fates to Direct Lesion Repair after Spinal Cord Injury" @default.
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- W2073103657 doi "https://doi.org/10.1523/jneurosci.4538-08.2009" @default.
- W2073103657 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2706133" @default.
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