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- W2073103685 abstract "The incidence of uterine bleeding and menstrual cycle modi fications in women receiving oral continuous chlormadinone acetate in microdoses is significant. In our experience 153 (39.2 %) out of 390 women presented some alterations in uterine bleeding while using this contraceptive method; amenorrhoea, for instance, was observed in 15 % of our subjects. However, the modifications of menstrual cycles were slightly less frequent (in 147 (37.6%) out of 390 treated subjects). The most annoying symptoms indeed were amenorrhoea, pro longed cycles, and intermenstrual bleeding. These alterations are apparently related to the anti oestrogenic effect of the progestogen and are shown by those subjects more sensitive to such action. Furthermore, our macroscopic and microscopical observations on ovaries of subjects treated with 0.5 mg. of chlormadinone daily, who presented prolonged menstrual cycles or amenorrhoea, showed that ovulation was inhibited. A marked effect of the compound at the endometrium stroma and glands was also evident (Zaflartu et al., 1967b). These findings help us to understand why additional oestrogen therapy given for a few days for bleeding and cycle regulation could eventually reverse the effect in cervical mucus of chlormadinone 0.5 mg. daily, and yet preserve the main contraceptive effect of the therapy at other levels of the repro ductive system (endometrium, endosalpinx). The gratifying action of the accessory oestrogens by correct ing uterine bleeding and regulating cycles significantly helps to improve the acceptability of this valuable contraceptive method. It has also been valuable in improving the accept ability of other progestogens in microdosage. Summary" @default.
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- W2073103685 date "1967-12-30" @default.
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- W2073103685 title "Transfer factor (diffusing capacity) for the lung in simple pneumoconiosis of coal workers." @default.
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- W2073103685 doi "https://doi.org/10.1136/bmj.4.5582.772" @default.
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