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- W2073103780 abstract "The 70% aqueous methanolic extract of the Chinese plant Aristolochia manshuriensis was found to contain two novel substituted phenanthrene compounds, SCH 546909 (1), and another phenanthrene glycoside (2). The structures of 1 and 2 were established based on NMR studies. They were identified as inhibitors of the CDK2 enzyme. Compound 1 was found to be a potent inhibitor of the CDK2 enzyme with an IC50 of 140 nM, whereas compound 2 was found to be less active with an IC50 of >10 microM." @default.
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- W2073103780 date "2010-02-01" @default.
- W2073103780 modified "2023-09-25" @default.
- W2073103780 title "New potential antitumor compounds from the plant Aristolochia manshuriensis as inhibitors of the CDK2 enzyme" @default.
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- W2073103780 doi "https://doi.org/10.1016/j.bmcl.2010.01.018" @default.
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