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- W2073105846 abstract "The lectin himehabu lectin (HHL) has recently been isolated from crude venom of the snake Trimeresurus okinavensis. Ca2+ -electrode and fluorescent Ca2+ -indicator experiments showed that HHL induced release of Ca2+ from the heavy fraction of skeletal muscle sarcoplasmic reticulum (HSR). The release of Ca2+ induced by caffeine from HSR was abolished by ryanodine, Mg2+ and ruthenium red, typical inhibitors of Ca2+ -release channels, whereas that induced by HHL was only partially reduced by these inhibitors. HHL, unlike caffeine, had no effect on [3H]ryanodine binding to HSR. These results suggest that HHL induces release of Ca2+ which is at least partially mediated through Ca2+ -release channels with novel pharmacological properties." @default.
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- W2073105846 date "1999-10-01" @default.
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- W2073105846 title "Himehabu Lectin, a Novel Inducer of Ca2+-release from the Venom of the Snake Trimeresurus okinavensis, in Sarcoplasmic Reticulum" @default.
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- W2073105846 doi "https://doi.org/10.1211/0022357991776750" @default.
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