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• W2073105900 abstract "Forty grass pollen hay fever patients were randomly divided into two equal groups and treated from January 1978 with different timothy grass pollen extracts: whole pollen allergens (WPA) (Alutard® SQ), a partially purified extract and purified pollen allergens (PPA) consisting of the major allergens 19, 25. The effect was evaluated by symptom scores in grass pollen season 1, 1978, and titrated thresholds of skin prick test (SPT) and nasal provocation test (NFT) with extracts WPA, PPA, and FGM (five-grass mixture). Extracts were biologically standardized in the HEP (histamine equivalent prick) system (1 HEP = 1,000 biological units (BU)/ml) and used in concentrations of 0.01-0.1-1.0-10 HEP for tests and treatment. The extracts for treatment were attached to Al (OH)3. Extracts from the same batch were used throughout the investigation. The two patient groups, WPA and PPA, were comparable us regards age, sex, total dosage (range 2,187–73,887 BU) and frequency of side effects. Fewer symptoms (P=0.0001) were observed with WPA than with PPA. Titrated threshold increase showed a treatment efficacy of 70–100% in SPT compared with 15–65% in NPT and tended to show higher protection after treatment with WPA titan PPA hut equal protection against WPA and FGM, in accordance with common allergens in various grass pollen. In SPT with WPA the threshold increase was correlated (P<0.05) to symptom scores. Frequency of major (urticaria, angioedema, asthma) general side effects was positively correlated (P0.05) to pretreatment NPT thresholds below 1 HEP and standard dosage at 1 HEP or more, but tended to a negative correlation with local side effects. All local and general side effects first appeared 1–5h after injection and a more careful dosage pattern than standard is recommendable at maximum concentration, 10 HEP, and also with extracts 1 HEP at pretreatment NPT thresholds below 1 HEP." @default.
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• W2073105900 date "1980-09-01" @default.
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• W2073105900 title "Immunotherapy in Hay Fever with Two Major Allergens 19, 25 and Partially Purified Extract of Timothy Grass Pollen." @default.
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• W2073105900 doi "https://doi.org/10.1111/j.1398-9995.1980.tb01795.x" @default.
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