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- W2073108501 abstract "Lesch–Nyhan disease (LND) is an inherited disorder associated with deficiency of hypoxanthine-guanine phosphoribosyltransferase (HPRT), an enzyme essential for purine recycling. The clinical manifestations of the disorder and several neurochemical studies have pointed towards a defect in the striatum, but histological studies of autopsied brain specimens have not revealed any consistent abnormalities. An HPRT-deficient (HPRT−) mouse that has been produced as a model for the disease also exhibits neurochemical abnormalities of the striatum without obvious histological correlates. In the current studies, Golgi-Cox histochemistry was used to evaluate the fine structure of medium spiny I neurons from the striatum in the HPRT− mice. To determine if any abnormalities might be restricted to striatal neurons, the pyramidal projection neurons of layer 5 of the cerebral cortex were also evaluated. Neurons from both regions demonstrated a normal distribution, orientation, and gross morphology. There was no evidence for an abnormal developmental process or degeneration. However, both regions demonstrated a paucity of neurons with very long dendrites and a reduction in dendritic spines that depended upon the distance from the cell body. These findings demonstrate that HPRT deficiency is associated with changes in neuronal architecture in the HPRT− mice. Similar abnormalities in the LND brain could underlie some of the clinical manifestations." @default.
- W2073108501 created "2016-06-24" @default.
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- W2073108501 date "2005-11-01" @default.
- W2073108501 modified "2023-10-17" @default.
- W2073108501 title "A Golgi study of neuronal architecture in a genetic mouse model for Lesch–Nyhan disease" @default.
- W2073108501 cites W151176851 @default.
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- W2073108501 cites W1966533136 @default.
- W2073108501 cites W1968358361 @default.
- W2073108501 cites W1969093476 @default.
- W2073108501 cites W1972810670 @default.
- W2073108501 cites W1988090530 @default.
- W2073108501 cites W1988625599 @default.
- W2073108501 cites W1989582746 @default.
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- W2073108501 doi "https://doi.org/10.1016/j.nbd.2005.04.005" @default.
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