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• W2073108780 abstract "SUMMARY: Immune abnormalities have been found in epileptic patients receiving antiepileptic drugs (AEDs). Phenytoin (PHT) produces a decrease in serum IgA and IgM levels and a decrease in blastic transformation of circulating lymphocytes stimulated with phytohemoagglutinin (PHA). The effects of carbamazepine (CBZ) on the immune response are still conflicting. To elucidate the effects of CBZ on some immunologic parameters, serum concentrations of IgA, IgG, IgM, the phagocytosis and killing properties of polymorphonuclear leukocytes (PMNs), the cytotoxic activity of natural killer cells and the response of lymphocytes to mitogenic agents were studied. Forty healthy individuals and 39 epileptic patients treated with carbamazepine (CBZ) monotherapy (age range 18–40 years) entered the study. Student's t test was used to evaluate the data. CBZ had no effect on the serum immunoglobulin concentrations or on lymphocytic reactivity to phytohemoagglutinin (PHA) mitogen. CBZ produced a significant enhancement of phagocytosis and killing properties of PMNs and an increase in natural killer (NK) cell activity. Therefore, a negative effect of CBZ therapy on the immune system was not observed in this study. RÉSUMÉ Des anomalies immunitaires ont été trouvées chez des patients traités par médicaments antépileptiques. La phénotoïne entraîne une diminution des IgA et IgM sériques, ainsi qu'une diminution de la transformation de lymphocytes circulants stimulés par phytohémagglutinine. Les effets de la carbamazépine (CBZ) sur la réponse immunitaire sont encore débattus. Pour clarifier cette question, les auteurs ont étudié les effets de la CBZ sur certains paramètres immunologiques: concentrations sériques en IgA, IgG, IgM, propriétés de phagocytose et de neutralisation des polynucléaires, activité cytotoxique des cellules killer naturelles, et réponses des lymphocytes aux agents mitogènes. RESUMEN En enfermos epitépticos que reciben medicaciones antiepilépticas se han encontrado anormalidades inmunológicas. La fenitoina produce una reduccién de los niveles séricos de IgA e IgM y una reducción de la transformación blástica de los linfocitos circulantes estimulada con fitohemoaglutinina. Los efectos de la carbamacepina (CBZ) sobre las respuestas inmunológicas son todavía conflictivos. Para aclarar los efectos de la CBZ sobre algunos parémetros inmunológicos se han estudiado los siguientes aspectos: las concentraciones séricas de IgA, IgG, e IgM, la fagocitosis y las propiedades “killer” de los leucocitos polimorfonucleares, la actividad citótoxica de las células “natural killer” y la respuesta de los linfocitos a los agentes mitogé-nicos. ZUSAMMENFASSUNG Bei Epileptikern unter Antiepileptika wurden verschiedene immunologische Auffalligkeiten gefunden: Phenytoin führt zu einem Abfall von Serum-IgA und IgM und eine Abnahme der blastischen Transformation von zirkulierenden Lymphozyten, die mit Phytohaemoagglutinin stimuliert wurden. Die Wirkungen von Carbamazepin (CBZ) auf die Immunantwort sind nach wie vor umstritten. Um die Wirkungen von Carbamazepin auf einige immunologische Parameter zu klären, wurden die Serumkonzentrationen von IgA, IgG, IgM, Phagozytose sowie Killereigenschaften von polymorphonukleären Leukozyten, die zytotoxische Aktivität von natürlichen Killerzellen und die Antwort von Lymphozyten auf Mitogene untersucht." @default.
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• W2073108780 date "1991-02-01" @default.
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• W2073108780 title "Immunologic Aspects of Carbamazepine Treatment in Epileptic Patients" @default.
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• W2073108780 doi "https://doi.org/10.1111/j.1528-1157.1991.tb05622.x" @default.
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