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• W2073110610 startingPage "818" @default.
• W2073110610 abstract "Irritable bowel syndrome (IBS) supports the concept of a dysregulated hypothalamic—pituitary—adrenal (HPA) axis. This study investigates the neuroendocrine and psychological responses to the acute physical stress of a lumbar puncture (LP) in women with diarrhea-predominant IBS by assessing central and peripheral HPA activity and affective measures. Blood samples have been collected at baseline and immediately post- and 1 hr following LP from 13 women with IBS and 13 controls. Plasma adrenocorticotropic hormone (ACTH), cortisol, epinephrine, and norepinephrine levels are analyzed. A single measure of cerebrospinal fluid (CSF) concentrations of corticotropin-releasing factor (CRF CSF ) and norepinephrine CSF is noted. Affective assessments are used to rate anxiety and depression with the Hospital Anxiety and Depression Scale (HADS) and acute mood state is rated using the Stress Symptom Rating questionnaire (stress, anxiety, anger, arousal). The women with IBS display blunted ACTH and cortisol responses to the LP along with a profile of affective responsiveness suggestive of chronic psychosocial stress, although no CRF CSF differences between groups are observed." @default.
• W2073110610 created "2016-06-24" @default.
• W2073110610 creator A5005469822 @default.
• W2073110610 creator A5021354923 @default.
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• W2073110610 date "2009-10-26" @default.
• W2073110610 modified "2023-09-23" @default.
• W2073110610 title "Hypothalamic—Pituitary— Adrenal Axis Dysregulation in Women With Irritable Bowel Syndrome in Response to Acute Physical Stress" @default.
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• W2073110610 doi "https://doi.org/10.1177/0193945909339320" @default.
• W2073110610 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19858523" @default.
• W2073110610 hasPublicationYear "2009" @default.
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