Matches in SemOpenAlex for { <https://semopenalex.org/work/W207312304> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W207312304 abstract "Abstract : Cancer is a disease associated with both germline and somatic mutation, and undoubtedly evolves in the host through increasingly malignant states by changes in the genome. Many of these changes can be seen by making gene copy number measurements, wherein increased copies of genes are associated with oncogenes and decreased copy numbers are associated with tumor suppressor genes. It is our hypothesis that these copy number changes, if measured with sufficient accuracy and resolution, can be used for two important purposes: to define precisely the mutant genes that cause cancer, and to define molecular markers that correlate with malignant potential and response to therapy. The technique we have developed, ROMA (representational oligonucleotide microarray analysis), accomplished this. We have completed data acquisition of approximately 200 breast cancer biopsies and cell lines. We discern many loci that are commonly deleted or amplified in breast cancer but not in normal genomes. Many of these loci confirm previous knowledge, but many are as yet unexplained. Our studies further suggests that genome instability, the presence of amplifications and deletions, is a marker for poor survival, and we have developed mathematical measures of copy number profiles that accurately predict." @default.
- W207312304 created "2016-06-24" @default.
- W207312304 creator A5000910342 @default.
- W207312304 date "2005-05-01" @default.
- W207312304 modified "2023-09-25" @default.
- W207312304 title "High Resolution Analysis of Copy Number Mutation in Breast Cancer" @default.
- W207312304 cites W1481143593 @default.
- W207312304 cites W1484187172 @default.
- W207312304 cites W1520880567 @default.
- W207312304 cites W1968046362 @default.
- W207312304 cites W1985995825 @default.
- W207312304 cites W1990208211 @default.
- W207312304 cites W2005453259 @default.
- W207312304 cites W2024081693 @default.
- W207312304 cites W2028102007 @default.
- W207312304 cites W2046101087 @default.
- W207312304 cites W2054875221 @default.
- W207312304 cites W2100668965 @default.
- W207312304 cites W2101833157 @default.
- W207312304 cites W2103308950 @default.
- W207312304 cites W2110065044 @default.
- W207312304 cites W2128628315 @default.
- W207312304 cites W2144662506 @default.
- W207312304 cites W2154361640 @default.
- W207312304 cites W2156643308 @default.
- W207312304 cites W3085162807 @default.
- W207312304 doi "https://doi.org/10.21236/ada438392" @default.
- W207312304 hasPublicationYear "2005" @default.
- W207312304 type Work @default.
- W207312304 sameAs 207312304 @default.
- W207312304 citedByCount "0" @default.
- W207312304 crossrefType "report" @default.
- W207312304 hasAuthorship W207312304A5000910342 @default.
- W207312304 hasConcept C104317684 @default.
- W207312304 hasConcept C120821319 @default.
- W207312304 hasConcept C121608353 @default.
- W207312304 hasConcept C138268822 @default.
- W207312304 hasConcept C141231307 @default.
- W207312304 hasConcept C154945302 @default.
- W207312304 hasConcept C163565370 @default.
- W207312304 hasConcept C166608930 @default.
- W207312304 hasConcept C41008148 @default.
- W207312304 hasConcept C501734568 @default.
- W207312304 hasConcept C530470458 @default.
- W207312304 hasConcept C54355233 @default.
- W207312304 hasConcept C70721500 @default.
- W207312304 hasConcept C86803240 @default.
- W207312304 hasConceptScore W207312304C104317684 @default.
- W207312304 hasConceptScore W207312304C120821319 @default.
- W207312304 hasConceptScore W207312304C121608353 @default.
- W207312304 hasConceptScore W207312304C138268822 @default.
- W207312304 hasConceptScore W207312304C141231307 @default.
- W207312304 hasConceptScore W207312304C154945302 @default.
- W207312304 hasConceptScore W207312304C163565370 @default.
- W207312304 hasConceptScore W207312304C166608930 @default.
- W207312304 hasConceptScore W207312304C41008148 @default.
- W207312304 hasConceptScore W207312304C501734568 @default.
- W207312304 hasConceptScore W207312304C530470458 @default.
- W207312304 hasConceptScore W207312304C54355233 @default.
- W207312304 hasConceptScore W207312304C70721500 @default.
- W207312304 hasConceptScore W207312304C86803240 @default.
- W207312304 hasLocation W2073123041 @default.
- W207312304 hasOpenAccess W207312304 @default.
- W207312304 hasPrimaryLocation W2073123041 @default.
- W207312304 hasRelatedWork W1996750246 @default.
- W207312304 hasRelatedWork W2016440433 @default.
- W207312304 hasRelatedWork W2090795400 @default.
- W207312304 hasRelatedWork W2117159036 @default.
- W207312304 hasRelatedWork W2167789523 @default.
- W207312304 hasRelatedWork W2252798758 @default.
- W207312304 hasRelatedWork W2378627662 @default.
- W207312304 hasRelatedWork W2417766600 @default.
- W207312304 hasRelatedWork W2419448289 @default.
- W207312304 hasRelatedWork W3024306633 @default.
- W207312304 isParatext "false" @default.
- W207312304 isRetracted "false" @default.
- W207312304 magId "207312304" @default.
- W207312304 workType "report" @default.