FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073123191> ?p ?o ?g. }

• W2073123191 endingPage "e6767" @default.
• W2073123191 startingPage "e6767" @default.
• W2073123191 abstract "Cytosine-5 methylation within CpG dinucleotides is a potentially important mechanism of epigenetic influence on human traits and disease. In addition to influences of age and gender, genetic control of DNA methylation levels has recently been described. We used whole blood genomic DNA in a twin set (23 MZ twin-pairs and 23 DZ twin-pairs, N = 92) as well as healthy controls (N = 96) to investigate heritability and relationship with age and gender of selected DNA methylation profiles using readily commercially available GoldenGate bead array technology. Despite the inability to detect meaningful methylation differences in the majority of CpG loci due to tissue type and locus selection issues, we found replicable significant associations of DNA methylation with age and gender. We identified associations of genetically heritable single nucleotide polymorphisms with large differences in DNA methylation levels near the polymorphism (cis effects) as well as associations with much smaller differences in DNA methylation levels elsewhere in the human genome (trans effects). Our results demonstrate the feasibility of array-based approaches in studies of DNA methylation and highlight the vast differences between individual loci. The identification of CpG loci of which DNA methylation levels are under genetic control or are related to age or gender will facilitate further studies into the role of DNA methylation and disease." @default.
• W2073123191 created "2016-06-24" @default.
• W2073123191 creator A5011661015 @default.
• W2073123191 creator A5022855713 @default.
• W2073123191 creator A5031613969 @default.
• W2073123191 creator A5036323969 @default.
• W2073123191 creator A5040907882 @default.
• W2073123191 creator A5053357058 @default.
• W2073123191 creator A5058124894 @default.
• W2073123191 creator A5068110851 @default.
• W2073123191 date "2009-08-26" @default.
• W2073123191 modified "2023-10-16" @default.
• W2073123191 title "The Relationship of DNA Methylation with Age, Gender and Genotype in Twins and Healthy Controls" @default.
• W2073123191 cites W1505696417 @default.
• W2073123191 cites W1965262464 @default.
• W2073123191 cites W1967340797 @default.
• W2073123191 cites W1975231696 @default.
• W2073123191 cites W1975364471 @default.
• W2073123191 cites W1976787939 @default.
• W2073123191 cites W1979452993 @default.
• W2073123191 cites W1991965466 @default.
• W2073123191 cites W1998517881 @default.
• W2073123191 cites W2003353769 @default.
• W2073123191 cites W2003402014 @default.
• W2073123191 cites W2004440539 @default.
• W2073123191 cites W2013223330 @default.
• W2073123191 cites W2020767030 @default.
• W2073123191 cites W2021469360 @default.
• W2073123191 cites W2028418054 @default.
• W2073123191 cites W2036440590 @default.
• W2073123191 cites W2077936220 @default.
• W2073123191 cites W2081872599 @default.
• W2073123191 cites W2094847578 @default.
• W2073123191 cites W2097459238 @default.
• W2073123191 cites W2099042456 @default.
• W2073123191 cites W2099907183 @default.
• W2073123191 cites W2121417064 @default.
• W2073123191 cites W2123427245 @default.
• W2073123191 cites W2124303397 @default.
• W2073123191 cites W2128676090 @default.
• W2073123191 cites W2129534676 @default.
• W2073123191 cites W2130189740 @default.
• W2073123191 cites W2130907138 @default.
• W2073123191 cites W2134555277 @default.
• W2073123191 cites W2137505881 @default.
• W2073123191 cites W2140980266 @default.
• W2073123191 cites W2143120330 @default.
• W2073123191 cites W2145913553 @default.
• W2073123191 cites W2148405421 @default.
• W2073123191 cites W2148521032 @default.
• W2073123191 cites W2151193284 @default.
• W2073123191 cites W2154711012 @default.
• W2073123191 cites W2157836366 @default.
• W2073123191 cites W2158384762 @default.
• W2073123191 cites W2161633633 @default.
• W2073123191 cites W2164673344 @default.
• W2073123191 cites W2166349250 @default.
• W2073123191 cites W2170634666 @default.
• W2073123191 cites W2587746491 @default.
• W2073123191 doi "https://doi.org/10.1371/journal.pone.0006767" @default.
• W2073123191 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2747671" @default.
• W2073123191 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19774229" @default.
• W2073123191 hasPublicationYear "2009" @default.
• W2073123191 type Work @default.
• W2073123191 sameAs 2073123191 @default.
• W2073123191 citedByCount "328" @default.
• W2073123191 countsByYear W20731231912012 @default.
• W2073123191 countsByYear W20731231912013 @default.
• W2073123191 countsByYear W20731231912014 @default.
• W2073123191 countsByYear W20731231912015 @default.
• W2073123191 countsByYear W20731231912016 @default.
• W2073123191 countsByYear W20731231912017 @default.
• W2073123191 countsByYear W20731231912018 @default.
• W2073123191 countsByYear W20731231912019 @default.
• W2073123191 countsByYear W20731231912020 @default.
• W2073123191 countsByYear W20731231912021 @default.
• W2073123191 countsByYear W20731231912022 @default.
• W2073123191 countsByYear W20731231912023 @default.
• W2073123191 crossrefType "journal-article" @default.
• W2073123191 hasAuthorship W2073123191A5011661015 @default.
• W2073123191 hasAuthorship W2073123191A5022855713 @default.
• W2073123191 hasAuthorship W2073123191A5031613969 @default.
• W2073123191 hasAuthorship W2073123191A5036323969 @default.
• W2073123191 hasAuthorship W2073123191A5040907882 @default.
• W2073123191 hasAuthorship W2073123191A5053357058 @default.
• W2073123191 hasAuthorship W2073123191A5058124894 @default.
• W2073123191 hasAuthorship W2073123191A5068110851 @default.
• W2073123191 hasBestOaLocation W20731231911 @default.
• W2073123191 hasConcept C104317684 @default.
• W2073123191 hasConcept C121912465 @default.
• W2073123191 hasConcept C135763542 @default.
• W2073123191 hasConcept C140173407 @default.
• W2073123191 hasConcept C150194340 @default.
• W2073123191 hasConcept C153209595 @default.
• W2073123191 hasConcept C161890455 @default.
• W2073123191 hasConcept C169594400 @default.
• W2073123191 hasConcept C190727270 @default.
• W2073123191 hasConcept C33288867 @default.

• next