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- W2073126069 abstract "Kinetochores form a dynamic interface with the microtubules from the mitotic spindle to achieve accurate chromosome segregation. Multiple proteins are assembled on centromeric DNA to form the kinetochore structure. Recent insights regarding the mechanism of kinetochore formation in vertebrate cells have come from the identification and characterization of kinetochore proteins using a variety of approaches. Constitutive centromere associated network (CCAN) proteins create a platform for kinetochore formation. Subsequently, CCAN proteins recruit outer kinetochore components such as KNL1, the Mis12 complex and the Ndc80 complex (KMN network) that attach to the spindle microtubules, together comprising the functional kinetochore. In this review, we introduce and discuss putative roles of CCAN and KMN proteins during the process of kinetochore formation." @default.
- W2073126069 created "2016-06-24" @default.
- W2073126069 creator A5036888639 @default.
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- W2073126069 date "2012-07-01" @default.
- W2073126069 modified "2023-10-18" @default.
- W2073126069 title "Molecular architecture of vertebrate kinetochores" @default.
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- W2073126069 doi "https://doi.org/10.1016/j.yexcr.2012.02.016" @default.
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