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- W2073129475 abstract "The synthesis and hybridization properties of an α-l-LNA analog where the 2′-oxygen atom is replaced with an exocyclic methylene group is reported. Contrary to the β-d series where the exocyclic methylene group is extremely well tolerated, this group was very poorly tolerated in the α-l-series and lead to duplex destabilization. Modeling studies showed that the exocyclic methylene group results in a steric clash with the nucleobase 3′ to the modified residue. Based on this structural model one can anticipate that replacing the 2′-oxygen atom of α-l-LNA with larger groups is likely to be detrimental to duplex stability. The model also provides insights into what type of 2′,4′-bridges are most likely to be tolerated in α-l-LNA modified oligonucleotide duplexes." @default.
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- W2073129475 date "2011-01-01" @default.
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- W2073129475 title "Replacing the 2′-oxygen with an exocyclic methylene group reverses the stabilization effects of α-l-LNA" @default.
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- W2073129475 doi "https://doi.org/10.1016/j.bmcl.2010.10.025" @default.
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