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- W2073130902 abstract "Border cells perform a collective, invasive, and directed migration during Drosophila melanogaster oogenesis. Two receptor tyrosine kinases (RTKs), the platelet-derived growth factor/vascular endothelial growth factor–related receptor (PVR) and the epidermal growth factor receptor (EGFR), are important for reading guidance cues, but how these cues steer migration is not well understood. During collective migration, front, back, and side extensions dynamically project from individual cells within the group. We find that guidance input from both RTKs affects the presence and size of these extensions, primarily by favoring the persistence of front extensions. Guidance cues also control the productivity of extensions, specifically rendering back extensions nonproductive. Early and late phases of border cell migration differ in efficiency of forward cluster movement, although motility of individual cells appears constant. This is caused by differences in behavioral effects of the RTKs: PVR dominantly induces large persistent front extensions and efficient streamlined group movement, whereas EGFR does not. Thus, guidance receptors steer movement of this cell group by differentially affecting multiple migration-related features." @default.
- W2073130902 created "2016-06-24" @default.
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- W2073130902 date "2011-02-07" @default.
- W2073130902 modified "2023-10-12" @default.
- W2073130902 title "Cell behaviors regulated by guidance cues in collective migration of border cells" @default.
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- W2073130902 doi "https://doi.org/10.1083/jcb.201010003" @default.
- W2073130902 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3101089" @default.
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