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- W2073132012 abstract "This study evaluated porcine natural killer cell cytotoxicity (NKCC), plasma cytokines including interleukin (IL) 1β, IL-6, IL-10, IL-12 and tumor necrosis factor-α and plasma stress-related hormones including prolactin (PRL), growth hormone (GH), β-endorphin (BEND), ACTH and cortisol (COR) during a 4 h restraint and recovery phase after saline or naloxone (1 mg/kg BW) administration. The restraint preceded with saline altered NKCC and IL-12 concentration (an early from15 to 60 min increase followed by a decrease) and increased other measured cytokines and hormones concentrations. Naloxone pretreatment blocked the suppressive effects of the restraint on NKCC and IL-12 and altered IL-10, IL-6, TNF-α, PRL and ACTH concentrations. Furthermore, in naloxone-injected pigs, a positive correlation was found between NKCC and all measured cytokines (with the exception of IL-6) and BEND, ACTH and COR. Results suggest that naloxone-sensitive opioid pathways could influence the mechanisms underlying the immune system (including NKCC) response during stress." @default.
- W2073132012 created "2016-06-24" @default.
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- W2073132012 date "2013-12-01" @default.
- W2073132012 modified "2023-09-27" @default.
- W2073132012 title "Natural killer cell cytotoxicity, cytokine and neuroendocrine responses to opioid receptor blockade during prolonged restraint in pigs" @default.
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- W2073132012 doi "https://doi.org/10.1016/j.rvsc.2013.09.017" @default.
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