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- W2073135856 abstract "The scaffolding protein ankyrin-G is required for Na(+) channel clustering at axon initial segments. It is also considered essential for Na(+) channel clustering at nodes of Ranvier to facilitate fast and efficient action potential propagation. However, notwithstanding these widely accepted roles, we show here that ankyrin-G is dispensable for nodal Na(+) channel clustering in vivo. Unexpectedly, in the absence of ankyrin-G, erythrocyte ankyrin (ankyrin-R) and its binding partner βI spectrin substitute for and rescue nodal Na(+) channel clustering. In addition, channel clustering is also rescued after loss of nodal βIV spectrin by βI spectrin and ankyrin-R. In mice lacking both ankyrin-G and ankyrin-R, Na(+) channels fail to cluster at nodes. Thus, ankyrin R-βI spectrin protein complexes function as secondary reserve Na(+) channel clustering machinery, and two independent ankyrin-spectrin protein complexes exist in myelinated axons to cluster Na(+) channels at nodes of Ranvier." @default.
- W2073135856 created "2016-06-24" @default.
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- W2073135856 date "2014-11-02" @default.
- W2073135856 modified "2023-09-27" @default.
- W2073135856 title "A hierarchy of ankyrin-spectrin complexes clusters sodium channels at nodes of Ranvier" @default.
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- W2073135856 doi "https://doi.org/10.1038/nn.3859" @default.
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