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- W2073135987 abstract "54 patients with the cœliac syndrome have been treated with a gluten-free diet and their response assessed. Only 70% returned quickly to full health. The remaining 30% who did not respond well could be separated into three groups according to their progress while on the diet. In group I there were 5 patients who deteriorated after gluten withdrawal and who were characterised by having a severe and extensive small intestinal mucosal lesion. The remarkable feature is in the histology of the jejunal mucosa where there is absence or striking diminution in the number of Paneth cells. The downward course is sometimes arrested with steroids. The 3 patients in group II remained chronically ill and have, in addition to a flat mucosal-biopsy specimen, pancreatic deficiency. The well-defined features in groups I and II make it possible to forecast their failure to respond to gluten withdrawal and afford some explanation of this failure. In group III were 8 patients who responded partially to gluten withdrawal, but the reason for this slow response is not yet explained." @default.
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- W2073135987 date "1967-02-01" @default.
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- W2073135987 title "RESPONSE TO A GLUTEN-FREE DIET OF PATIENTS WITH THE CŒLIAC SYNDROME" @default.
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- W2073135987 doi "https://doi.org/10.1016/s0140-6736(67)91238-x" @default.
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