FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073142788> ?p ?o ?g. }

• W2073142788 endingPage "5550" @default.
• W2073142788 startingPage "5543" @default.
• W2073142788 abstract "To explore adjuvants that are capable of promoting Th1-biased immune response, we investigated the usefulness of levamisole (LMS) as one such adjuvant for two different preparations of killed viral vaccines, derived from the foot mouth disease virus (FMDV) or the porcine respiratory reproductive syndrome virus (PRRSV) and tested respectively in BALB/c or C57 BL/6 mice. The results showed that LMS induced different types of immune responses in the host, depending on its dosage. While a high level of serum IgG was induced by using LMS at 2%, the most robust T cell proliferation was induced with LMS at 0.5%. The Th1 and Th2 cytokine profiles, which tracked well with the antibody and T cell responses, were similarly influenced by the dose of LMS. Moreover, the enhanced T cell response correlated with increased expression of MHC and co-stimulatory molecules and decreased expression of the suppressors of cytokine signaling molecules (SOCS1 and SOCS3) in the spleen, suggesting that it is mediated by the antigen presentation, co-stimulator signaling, and cytokine production pathways. These results establish that LMS can be used to induce Th1-biased immune responses when combined with killed-virus-based antiviral vaccines and that such adjuvant effect depends on the optimal LMS dosage." @default.
• W2073142788 created "2016-06-24" @default.
• W2073142788 creator A5002438532 @default.
• W2073142788 creator A5003862415 @default.
• W2073142788 creator A5006378406 @default.
• W2073142788 creator A5049608805 @default.
• W2073142788 creator A5080129378 @default.
• W2073142788 creator A5081493680 @default.
• W2073142788 creator A5082213642 @default.
• W2073142788 creator A5082476919 @default.
• W2073142788 creator A5085827001 @default.
• W2073142788 creator A5089545257 @default.
• W2073142788 date "2005-12-01" @default.
• W2073142788 modified "2023-09-30" @default.
• W2073142788 title "The adjuvant effect of levamisole on killed viral vaccines" @default.
• W2073142788 cites W1598767638 @default.
• W2073142788 cites W1967486091 @default.
• W2073142788 cites W1968114019 @default.
• W2073142788 cites W1969510504 @default.
• W2073142788 cites W1970972550 @default.
• W2073142788 cites W1977422834 @default.
• W2073142788 cites W1977437107 @default.
• W2073142788 cites W1987016144 @default.
• W2073142788 cites W1988105373 @default.
• W2073142788 cites W2003444408 @default.
• W2073142788 cites W2011302465 @default.
• W2073142788 cites W2013363382 @default.
• W2073142788 cites W2020393204 @default.
• W2073142788 cites W2035163760 @default.
• W2073142788 cites W2037835195 @default.
• W2073142788 cites W2048847638 @default.
• W2073142788 cites W2051307768 @default.
• W2073142788 cites W2055942373 @default.
• W2073142788 cites W2068105830 @default.
• W2073142788 cites W2088595871 @default.
• W2073142788 cites W2089127654 @default.
• W2073142788 cites W2101363646 @default.
• W2073142788 cites W2168931543 @default.
• W2073142788 cites W2255487108 @default.
• W2073142788 cites W2313857605 @default.
• W2073142788 cites W2323969141 @default.
• W2073142788 cites W63837087 @default.
• W2073142788 doi "https://doi.org/10.1016/j.vaccine.2005.07.017" @default.
• W2073142788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16095767" @default.
• W2073142788 hasPublicationYear "2005" @default.
• W2073142788 type Work @default.
• W2073142788 sameAs 2073142788 @default.
• W2073142788 citedByCount "35" @default.
• W2073142788 countsByYear W20731427882012 @default.
• W2073142788 countsByYear W20731427882013 @default.
• W2073142788 countsByYear W20731427882014 @default.
• W2073142788 countsByYear W20731427882015 @default.
• W2073142788 countsByYear W20731427882016 @default.
• W2073142788 countsByYear W20731427882017 @default.
• W2073142788 countsByYear W20731427882018 @default.
• W2073142788 countsByYear W20731427882020 @default.
• W2073142788 countsByYear W20731427882022 @default.
• W2073142788 countsByYear W20731427882023 @default.
• W2073142788 crossrefType "journal-article" @default.
• W2073142788 hasAuthorship W2073142788A5002438532 @default.
• W2073142788 hasAuthorship W2073142788A5003862415 @default.
• W2073142788 hasAuthorship W2073142788A5006378406 @default.
• W2073142788 hasAuthorship W2073142788A5049608805 @default.
• W2073142788 hasAuthorship W2073142788A5080129378 @default.
• W2073142788 hasAuthorship W2073142788A5081493680 @default.
• W2073142788 hasAuthorship W2073142788A5082213642 @default.
• W2073142788 hasAuthorship W2073142788A5082476919 @default.
• W2073142788 hasAuthorship W2073142788A5085827001 @default.
• W2073142788 hasAuthorship W2073142788A5089545257 @default.
• W2073142788 hasConcept C126042315 @default.
• W2073142788 hasConcept C147483822 @default.
• W2073142788 hasConcept C159047783 @default.
• W2073142788 hasConcept C159654299 @default.
• W2073142788 hasConcept C203014093 @default.
• W2073142788 hasConcept C2522874641 @default.
• W2073142788 hasConcept C2776090121 @default.
• W2073142788 hasConcept C2777863537 @default.
• W2073142788 hasConcept C2778690821 @default.
• W2073142788 hasConcept C2778923194 @default.
• W2073142788 hasConcept C2781325985 @default.
• W2073142788 hasConcept C55493867 @default.
• W2073142788 hasConcept C62478195 @default.
• W2073142788 hasConcept C86803240 @default.
• W2073142788 hasConcept C8891405 @default.
• W2073142788 hasConceptScore W2073142788C126042315 @default.
• W2073142788 hasConceptScore W2073142788C147483822 @default.
• W2073142788 hasConceptScore W2073142788C159047783 @default.
• W2073142788 hasConceptScore W2073142788C159654299 @default.
• W2073142788 hasConceptScore W2073142788C203014093 @default.
• W2073142788 hasConceptScore W2073142788C2522874641 @default.
• W2073142788 hasConceptScore W2073142788C2776090121 @default.
• W2073142788 hasConceptScore W2073142788C2777863537 @default.
• W2073142788 hasConceptScore W2073142788C2778690821 @default.
• W2073142788 hasConceptScore W2073142788C2778923194 @default.
• W2073142788 hasConceptScore W2073142788C2781325985 @default.
• W2073142788 hasConceptScore W2073142788C55493867 @default.
• W2073142788 hasConceptScore W2073142788C62478195 @default.
• W2073142788 hasConceptScore W2073142788C86803240 @default.

• next