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- W2073152739 abstract "Mefloquine hydrochloride, a new 4-quinolinemethanol, was administered as a single oral dose to 47 volunteers infected with malaria. Treatment resulted in rapid clearance of fever and parasitemia. No recrudescence of parasites was observed after treatment of chloroquine-sensitive infections of Plasmodium falciparum. More significantly, in nonimmune persons with chloroquine-resistant infections, 1 gram of mefloquine cured 10 of 12 patients and 1.5 grams cured all 8 patients who received this dose of the drug. The marked activity of a single dose of mefloquine against chloroquine-resistant strains of Plasmodium falciparum suggests that this agent may be more useful than currently available drugs are for the treatment of drug-resistant malaria." @default.
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- W2073152739 date "1975-11-21" @default.
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- W2073152739 title "Mefloquine (WR 142,490) in the Treatment of Human Malaria" @default.
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- W2073152739 doi "https://doi.org/10.1126/science.1105787" @default.
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