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- W2073160625 abstract "Several emerging lines of evidence support an anti-inflammatory role for nicotinamide and other vitamin B components. However, the mechanisms underlying their activity remain unclear. In the present study, we investigated the ability of nicotinamide to inhibit both neutrophil recruitment in IL-8-, LTB4- or carrageenan-induced pleurisy in mice and the rolling and adherence of neutrophils. Nicotinamide inhibited IL-8-, LTB4- and carrageenan-induced neutrophil migration, KC production and carrageenan-induced neutrophil rolling and adherence. We propose that the effects of nicotinamide in inhibiting neutrophil recruitment in carrageenan-induced pleurisy may be due to the ability of nicotinamide to inhibit the action of IL-8 and LTB4, decrease KC production, and inhibit early events that regulate leukocyte migration from blood vessels into tissue." @default.
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- W2073160625 date "2012-06-01" @default.
- W2073160625 modified "2023-09-30" @default.
- W2073160625 title "Neutrophil recruitment is inhibited by nicotinamide in experimental pleurisy in mice" @default.
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- W2073160625 doi "https://doi.org/10.1016/j.ejphar.2012.04.014" @default.
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