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• W2073160834 abstract "Using structure-based drug design principles, we identified opportunities to reduce the lipophilicity of our tertiary sulfonamide RORc inverse agonists. The new analogs possessed improved RORc cellular potencies with >77-fold selectivity for RORc over other nuclear receptors in our cell assay suite. The reduction in lipophilicity also led to an increased plasma–protein unbound fraction and improvements in cellular permeability and aqueous solubility." @default.
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• W2073160834 date "2014-08-01" @default.
• W2073160834 modified "2023-09-23" @default.
• W2073160834 title "Reduction in lipophilicity improved the solubility, plasma–protein binding, and permeability of tertiary sulfonamide RORc inverse agonists" @default.
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• W2073160834 doi "https://doi.org/10.1016/j.bmcl.2014.06.048" @default.
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