Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073162572> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W2073162572 abstract "We have studied the effects of acetylcholine (ACh), and other agents that modulate pancreatic bicarbonate secretion, on the anion permeability of a human ductal adenocarcinoma cell line (BxPC-3). Anion permeability was monitored using an 125I efflux assay. ACh (10 microM) markedly stimulated 125I efflux from BxPC-3 cells and this response was abolished by atropine (10 microM), indicating that it is mediated by muscarinic receptors. Using transport inhibitors and ionophores, we obtained data indicating that some of the ACh-induced 125I efflux results from the opening of K+ channels, which would hyperpolarise the cell and increase the electrical driving force for 125I exit. The remaining ACh-induced 125I efflux is not mediated by anion exchangers or by Na+/K+/2Cl- cotransporters, and is probably explained by activation of an anion channel in the BxPC-3 cell membrane. Ionomycin (0.5 microM) caused a small rise in 125I efflux, indicating that this process can be triggered by an increase in intracellular calcium concentration. ATP (100 microM), ADP (100 microM), bombesin (10 nM), and cholecystokinin (CCK) (10 nM) also stimulated 125I efflux, indicating that receptors for these agents are expressed on BxPC-3 cells. We speculate that bicarbonate secretion from the human pancreas could be modulated by ACh, ATP, bombesin, and CCK via a direct effect on the duct cell." @default.
- W2073162572 created "2016-06-24" @default.
- W2073162572 creator A5006156872 @default.
- W2073162572 creator A5015970126 @default.
- W2073162572 creator A5082833471 @default.
- W2073162572 date "1994-09-01" @default.
- W2073162572 modified "2023-10-18" @default.
- W2073162572 title "Acetylcholine, ATP, Bombesin, and Cholecystokinin Stimulate 125I Efflux from a Human Pancreatic Adenocarcinoma Cell Line (BxPC-3)" @default.
- W2073162572 doi "https://doi.org/10.1097/00006676-199409000-00010" @default.
- W2073162572 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7528918" @default.
- W2073162572 hasPublicationYear "1994" @default.
- W2073162572 type Work @default.
- W2073162572 sameAs 2073162572 @default.
- W2073162572 citedByCount "8" @default.
- W2073162572 countsByYear W20731625722013 @default.
- W2073162572 crossrefType "journal-article" @default.
- W2073162572 hasAuthorship W2073162572A5006156872 @default.
- W2073162572 hasAuthorship W2073162572A5015970126 @default.
- W2073162572 hasAuthorship W2073162572A5082833471 @default.
- W2073162572 hasConcept C118303440 @default.
- W2073162572 hasConcept C126322002 @default.
- W2073162572 hasConcept C134018914 @default.
- W2073162572 hasConcept C170493617 @default.
- W2073162572 hasConcept C185592680 @default.
- W2073162572 hasConcept C200082930 @default.
- W2073162572 hasConcept C2775910092 @default.
- W2073162572 hasConcept C2777593968 @default.
- W2073162572 hasConcept C2778448772 @default.
- W2073162572 hasConcept C2778677841 @default.
- W2073162572 hasConcept C49039625 @default.
- W2073162572 hasConcept C55493867 @default.
- W2073162572 hasConcept C71924100 @default.
- W2073162572 hasConcept C79879829 @default.
- W2073162572 hasConcept C86803240 @default.
- W2073162572 hasConceptScore W2073162572C118303440 @default.
- W2073162572 hasConceptScore W2073162572C126322002 @default.
- W2073162572 hasConceptScore W2073162572C134018914 @default.
- W2073162572 hasConceptScore W2073162572C170493617 @default.
- W2073162572 hasConceptScore W2073162572C185592680 @default.
- W2073162572 hasConceptScore W2073162572C200082930 @default.
- W2073162572 hasConceptScore W2073162572C2775910092 @default.
- W2073162572 hasConceptScore W2073162572C2777593968 @default.
- W2073162572 hasConceptScore W2073162572C2778448772 @default.
- W2073162572 hasConceptScore W2073162572C2778677841 @default.
- W2073162572 hasConceptScore W2073162572C49039625 @default.
- W2073162572 hasConceptScore W2073162572C55493867 @default.
- W2073162572 hasConceptScore W2073162572C71924100 @default.
- W2073162572 hasConceptScore W2073162572C79879829 @default.
- W2073162572 hasConceptScore W2073162572C86803240 @default.
- W2073162572 hasLocation W20731625721 @default.
- W2073162572 hasLocation W20731625722 @default.
- W2073162572 hasOpenAccess W2073162572 @default.
- W2073162572 hasPrimaryLocation W20731625721 @default.
- W2073162572 hasRelatedWork W19226543 @default.
- W2073162572 hasRelatedWork W2013346368 @default.
- W2073162572 hasRelatedWork W2020703384 @default.
- W2073162572 hasRelatedWork W2073043414 @default.
- W2073162572 hasRelatedWork W2073162572 @default.
- W2073162572 hasRelatedWork W2406336281 @default.
- W2073162572 hasRelatedWork W2407736160 @default.
- W2073162572 hasRelatedWork W2418050388 @default.
- W2073162572 hasRelatedWork W2473249024 @default.
- W2073162572 hasRelatedWork W318573999 @default.
- W2073162572 isParatext "false" @default.
- W2073162572 isRetracted "false" @default.
- W2073162572 magId "2073162572" @default.
- W2073162572 workType "article" @default.