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- W2073162767 abstract "Endothelial cell (EC) alignment to directional flow or stretch supports anti-inflammatory functions, but mechanisms controlling polarized structural adaptation in response to physical cues remain unclear. This study aimed to determine whether factors associated with early actin edge ruffling implicated in cell polarization are prerequisite for stress fiber (SF) reorientation in response to cyclic uniaxial stretch. Time-lapse analysis of EGFP-actin in confluent ECs showed that onset of either cyclic uniaxial or equibiaxial stretch caused a non-directional increase in edge ruffling. Edge activity was concentrated in a direction perpendicular to the stretch axis after 60 min, consistent with the direction of SF alignment. Rho-kinase inhibition caused reorientation of both stretch-induced edge ruffling and SF alignment parallel to the stretch axis. Arp2/3 inhibition attenuated stretch-induced cell elongation and disrupted polarized edge dynamics and microtubule organizing center reorientation, but it had no effect on the extent of SF reorientation. Disrupting localization of p21-activated kinase did not prevent stretch-induced SF reorientation, suggesting that this Rac effector is not critical in regulating stretch-induced cytoskeletal remodeling. Overall, these results suggest that directional edge ruffling is not a primary mechanism that guides SF reorientation in response to stretch; the two events are coincident but not causal." @default.
- W2073162767 created "2016-06-24" @default.
- W2073162767 creator A5013069120 @default.
- W2073162767 creator A5024393630 @default.
- W2073162767 date "2014-12-09" @default.
- W2073162767 modified "2023-09-26" @default.
- W2073162767 title "Polarized Actin Structural Dynamics in Response to Cyclic Uniaxial Stretch" @default.
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- W2073162767 doi "https://doi.org/10.1007/s12195-014-0370-7" @default.
- W2073162767 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4372154" @default.
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