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• W2073162806 abstract "The pharmacokinetics and pharmacodynamics of atenolol and timolol were studied in six extensive and four poor metabolisers of debrisoquine. There was a significant correlation between the debrisoquine to 4-hydroxydebrisoquine ratio and the area under the plasma concentration time curve (AUC) for timolol (rs = 0.75, P less than 0.02). The mean of the AUC values for timolol was significantly greater in the poor metabolisers than in the extensive metabolisers (P less than 0.05). There was a significant correlation between the debrisoquine to 4-hydroxydebrisoquine ratio and beta-adrenoceptor blockade 24 h after dosing with timolol (rs = 0.66, P less than 0.05). The mean degree of beta-adrenoceptor blockade was significantly greater in the poor metabolisers than in the extensive metabolisers 24 h after dosing with timolol (P less than 0.01). There was no relation between the debrisoquine to 4-hydroxydebrisoquine ratio and the pharmacokinetics or pharmacodynamics of atenolol." @default.
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• W2073162806 date "1985-03-01" @default.
• W2073162806 modified "2023-10-10" @default.
• W2073162806 title "Timolol and atenolol: relationships between oxidation phenotype, pharmacokinetics and pharmacodynamics." @default.
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• W2073162806 doi "https://doi.org/10.1111/j.1365-2125.1985.tb02651.x" @default.
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