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- W2073166657 abstract "Kearon C, Ginsberg JS, Douketis J, et al. A randomized trial of diagnostic strategies after normal proximal vein ultrasonography for suspected deep venous thrombosis: D-dimer testing compared with repeated ultrasonography. Ann Intern Med 2005;142:490–6. [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] Q In patients with suspected deep venous thrombosis (DVT) and negative results on proximal vein ultrasonography, how does a D-dimer–based management strategy that minimises additional assessments compare with routine repeated ultrasonography? Clinical impact ratings IM/Ambulatory care ★★★★★★☆ Emergency medicine ★★★★★☆☆ Haematology ★★★★★★☆ ### ![Graphic][5]</img>Design: randomised controlled trial. ### ![Graphic][6]</img>Allocation: concealed.* ### ![Graphic][7]</img>Blinding: blinded (outcome assessors).* ### ![Graphic][8]</img>Follow up period: 6 months. ### ![Graphic][9]</img>Setting: thrombosis services of 4 university hospitals in Hamilton, Ontario, Canada. ### ![Graphic][10]</img>Patients: 810 patients (mean age 59.5 y, 62% women) with a suspected first episode of DVT and negative results on proximal vein ultrasonography who were referred by primary care and hospital-based physicians to a thrombosis outpatient service. Exclusion criteria included life expectancy <6 months, contraindication to venography, use of full dose heparin for >48 hours, use of long term warfarin therapy, symptoms of pulmonary embolism, and … [1]: {openurl}?query=rft.jtitle%253DAnnals%2Bof%2BInternal%2BMedicine%26rft.stitle%253DANN%2BINTERN%2BMED%26rft.issn%253D0003-4819%26rft.aulast%253DKearon%26rft.auinit1%253DC.%26rft.volume%253D142%26rft.issue%253D7%26rft.spage%253D490%26rft.epage%253D496%26rft.atitle%253DA%2BRandomized%2BTrial%2Bof%2BDiagnostic%2BStrategies%2Bafter%2BNormal%2BProximal%2BVein%2BUltrasonography%2Bfor%2BSuspected%2BDeep%2BVenous%2BThrombosis%253A%2BD-Dimer%2BTesting%2BCompared%2Bwith%2BRepeated%2BUltrasonography%26rft_id%253Dinfo%253Adoi%252F10.7326%252F0003-4819-142-7-200504050-00007%26rft_id%253Dinfo%253Apmid%252F15809460%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.7326/0003-4819-142-7-200504050-00007&link_type=DOI [3]: /lookup/external-ref?access_num=15809460&link_type=MED&atom=%2Febmed%2F10%2F6%2F179.atom [4]: /lookup/external-ref?access_num=000228167800002&link_type=ISI [5]: /embed/inline-graphic-1.gif [6]: /embed/inline-graphic-2.gif [7]: /embed/inline-graphic-3.gif [8]: /embed/inline-graphic-4.gif [9]: /embed/inline-graphic-5.gif [10]: /embed/inline-graphic-6.gif" @default.
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- W2073166657 date "2005-12-01" @default.
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- W2073166657 title "Safety of a D-dimer based strategy and repeated ultrasonography did not differ in DVT and normal proximal vein ultrasonography" @default.
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!["Kearon C, Ginsberg JS, Douketis J, et al. A randomized trial of diagnostic strategies after normal proximal vein ultrasonography for suspected deep venous thrombosis: D-dimer testing compared with repeated ultrasonography. Ann Intern Med 2005;142:490–6. [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] Q In patients with suspected deep venous thrombosis (DVT) and negative results on proximal vein ultrasonography, how does a D-dimer–based management strategy that minimises additional assessments compare with routine repeated ultrasonography? Clinical impact ratings IM/Ambulatory care ★★★★★★☆ Emergency medicine ★★★★★☆☆ Haematology ★★★★★★☆ ### ![Graphic][5]</img>Design: randomised controlled trial. ### ![Graphic][6]</img>Allocation: concealed.* ### ![Graphic][7]</img>Blinding: blinded (outcome assessors).* ### ![Graphic][8]</img>Follow up period: 6 months. ### ![Graphic][9]</img>Setting: thrombosis services of 4 university hospitals in Hamilton, Ontario, Canada. ### ![Graphic][10]</img>Patients: 810 patients (mean age 59.5 y, 62% women) with a suspected first episode of DVT and negative results on proximal vein ultrasonography who were referred by primary care and hospital-based physicians to a thrombosis outpatient service. Exclusion criteria included life expectancy <6 months, contraindication to venography, use of full dose heparin for >48 hours, use of long term warfarin therapy, symptoms of pulmonary embolism, and … [1]: 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