Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073166896> ?p ?o ?g. }
- W2073166896 endingPage "311" @default.
- W2073166896 startingPage "301" @default.
- W2073166896 abstract "Background The amygdala plays a central role in the fronto-limbic network involved in the processing of emotions. Structural and functional abnormalities of the amygdala have recently been found in schizophrenia, although there are still contradictory results about its reduced or preserved volumes. Method In order to address these contradictory findings and to further elucidate the possibly underlying pathophysiological process of the amygdala, we employed structural magnetic resonance imaging (MRI) and diffusion weighted imaging (DWI), exploring amygdalar volume and microstructural changes in 69 patients with schizophrenia and 72 matched healthy subjects, relating these indices to psychopathological measures. Results Measuring water diffusivity, the apparent diffusion coefficients (ADCs) for the right amygdala were found to be significantly greater in patients with schizophrenia compared with healthy controls, with a trend for abnormally reduced volumes. Also, significant correlations between mood symptoms and amygdalar volumes were found in schizophrenia. Conclusions We therefore provide evidence that schizophrenia is associated with disrupted tissue organization of the right amygdala, despite partially preserved size, which may ultimately lead to abnormal emotional processing in schizophrenia. This result confirms the major role of the amygdala in the pathophysiology of schizophrenia and is discussed with respect to amygdalar structural and functional abnormalities found in patients suffering from this illness." @default.
- W2073166896 created "2016-06-24" @default.
- W2073166896 creator A5010384413 @default.
- W2073166896 creator A5014703508 @default.
- W2073166896 creator A5017273160 @default.
- W2073166896 creator A5017804271 @default.
- W2073166896 creator A5020923936 @default.
- W2073166896 creator A5027230168 @default.
- W2073166896 creator A5031578782 @default.
- W2073166896 creator A5033392187 @default.
- W2073166896 creator A5033626750 @default.
- W2073166896 creator A5038704070 @default.
- W2073166896 creator A5055899334 @default.
- W2073166896 creator A5064520148 @default.
- W2073166896 creator A5084987657 @default.
- W2073166896 date "2010-05-12" @default.
- W2073166896 modified "2023-10-17" @default.
- W2073166896 title "Altered microstructure integrity of the amygdala in schizophrenia: a bimodal MRI and DWI study" @default.
- W2073166896 cites W1606131697 @default.
- W2073166896 cites W1883268346 @default.
- W2073166896 cites W1965790905 @default.
- W2073166896 cites W1965924747 @default.
- W2073166896 cites W1967786852 @default.
- W2073166896 cites W1969319053 @default.
- W2073166896 cites W1971847861 @default.
- W2073166896 cites W1981205427 @default.
- W2073166896 cites W1986063939 @default.
- W2073166896 cites W1988196101 @default.
- W2073166896 cites W1989278867 @default.
- W2073166896 cites W1991949265 @default.
- W2073166896 cites W1992038195 @default.
- W2073166896 cites W1996015773 @default.
- W2073166896 cites W1997597038 @default.
- W2073166896 cites W1999903950 @default.
- W2073166896 cites W2000628954 @default.
- W2073166896 cites W2001362807 @default.
- W2073166896 cites W2003015777 @default.
- W2073166896 cites W2007049689 @default.
- W2073166896 cites W2008195666 @default.
- W2073166896 cites W2008873264 @default.
- W2073166896 cites W2015287319 @default.
- W2073166896 cites W2016912409 @default.
- W2073166896 cites W2019299015 @default.
- W2073166896 cites W2022693243 @default.
- W2073166896 cites W2022935708 @default.
- W2073166896 cites W2024030091 @default.
- W2073166896 cites W2024134876 @default.
- W2073166896 cites W2026226974 @default.
- W2073166896 cites W2026765475 @default.
- W2073166896 cites W2026812901 @default.
- W2073166896 cites W2035245686 @default.
- W2073166896 cites W2040422099 @default.
- W2073166896 cites W2040690461 @default.
- W2073166896 cites W2043348039 @default.
- W2073166896 cites W2054034441 @default.
- W2073166896 cites W2054037636 @default.
- W2073166896 cites W2062187033 @default.
- W2073166896 cites W2065931730 @default.
- W2073166896 cites W2067134920 @default.
- W2073166896 cites W2068579083 @default.
- W2073166896 cites W2070287713 @default.
- W2073166896 cites W2070343155 @default.
- W2073166896 cites W2080086149 @default.
- W2073166896 cites W2085473431 @default.
- W2073166896 cites W2088007245 @default.
- W2073166896 cites W2094475773 @default.
- W2073166896 cites W2100728134 @default.
- W2073166896 cites W2105750011 @default.
- W2073166896 cites W2105910682 @default.
- W2073166896 cites W2107150572 @default.
- W2073166896 cites W2111646863 @default.
- W2073166896 cites W2112300402 @default.
- W2073166896 cites W2113118665 @default.
- W2073166896 cites W2116087808 @default.
- W2073166896 cites W2117023114 @default.
- W2073166896 cites W2120906765 @default.
- W2073166896 cites W2126572298 @default.
- W2073166896 cites W2127811322 @default.
- W2073166896 cites W2129500763 @default.
- W2073166896 cites W2130721148 @default.
- W2073166896 cites W2132406375 @default.
- W2073166896 cites W2134789197 @default.
- W2073166896 cites W2137744200 @default.
- W2073166896 cites W2137811349 @default.
- W2073166896 cites W2151602940 @default.
- W2073166896 cites W2156123885 @default.
- W2073166896 cites W2158553737 @default.
- W2073166896 cites W2161266529 @default.
- W2073166896 cites W2164343322 @default.
- W2073166896 cites W2167452733 @default.
- W2073166896 cites W2169733554 @default.
- W2073166896 cites W2169894394 @default.
- W2073166896 cites W2170391530 @default.
- W2073166896 cites W2206955164 @default.
- W2073166896 cites W2208162306 @default.
- W2073166896 cites W2218229344 @default.
- W2073166896 cites W2263555737 @default.
- W2073166896 cites W4237755397 @default.