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• W2073167413 abstract "The catalase activity in the liver, kidney, lung, and blood hemolysate was measured in newborn, 21-, 70-, 175-, and >400-day-old mice from the strains BALB/c, Cs b , C3H/HeSnJ, C3H/S, C57BL/6J, SW, and 129/ReJ. Catalase activity was found to be highest in the liver (~0.33 U/mg protein) followed by the kidney (~0.13 U/mg protein), lung (~0.05 U/mg protein), and blood hemolysate (~0.03 U/mg protein). ANOVA analysis indicated significant differences in enzyme activity among strains and age groups studied. The developmental profiles of enzyme activity were tissue and strain specific. Catalase activity in the blood, for example, was generally higher at birth and at old age, whereas the kidney catalase activity was low at birth and increased substantially with age. Strains could be classified as normal (129/ReJ, BALB/c, C3H/HeSnJ, C3H/S), hypocatalasemic (C57BL/6J, SW), and acatalasemic (Cs b ) with respect to enzyme activity and it was on this basis that the inheritance of the catalase phenotype was studied using appropriate crosses. The enzyme activity level in each tissue appears to be governed by a unique set of genetic regulators/modifiers that interact with a single structural gene (Cs) or its product to produce the catalase phenotype. Some of these (e.g., Ce-1 and Ce-2) have been previously described but based on the results of various crosses reported here, more must exist that remain still uncharacterized at the molecular level. Models proposed for the inheritance of the catalase phenotype vary in complexity from single allelic differences between strains (e.g., BALB/c × Cs b ; blood) to a system of multiple interacting genetic determinants (e.g., BALB/c × Cs b ; liver) each having dominant (e.g., C57BL/6J over BALB/c; liver) and recessive components (e.g., gene(s) conferring the acatalasemic phenotype in BALB/c × Cs b ; blood and kidney). Such results are important and offer an interesting model to further characterize aspects of eukaryotic gene regulation. Key words: catalase, inbred mice, tissue specificity, developmental profile, inheritance." @default.
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• W2073167413 date "1987-10-01" @default.
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• W2073167413 title "Inheritance and expression of tissue-specific catalase activity during development and aging in mice" @default.
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• W2073167413 doi "https://doi.org/10.1139/g87-127" @default.
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