Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073168217> ?p ?o ?g. }
- W2073168217 endingPage "301" @default.
- W2073168217 startingPage "287" @default.
- W2073168217 abstract "The transformation of melanocytes to melanoma cells is characterised by abnormal proliferation resulting from alterations in cell cycle regulatory mechanisms. This occurs through alterations in the two major cell cycle regulatory pathways, the retinoblastoma (Rb) and p53 tumour suppressor pathways. This review summarises the current knowledge of alterations in these two pathways at G1/S transition and specifically the role of the key cell cycle regulatory proteins pRb, p16INK4a (p16), cyclin D1, p27Kip1 (p27), p53 and p21Waf1/Cip1 (p21) in the pathogenesis of melanoma. It also considers their prognostic significance. Current data indicate that alterations of cyclin kinase inhibitor (cdki) levels are implicated in the pathogenesis of melanoma and may be useful prognostic markers. However, large validation studies linked to comprehensive clinical follow up data are necessary to clarify the prognostic significance of cell cycle regulatory proteins in individual patients." @default.
- W2073168217 created "2016-06-24" @default.
- W2073168217 creator A5000432967 @default.
- W2073168217 creator A5035263718 @default.
- W2073168217 creator A5050438949 @default.
- W2073168217 creator A5064335485 @default.
- W2073168217 creator A5080490149 @default.
- W2073168217 creator A5083653505 @default.
- W2073168217 creator A5085289118 @default.
- W2073168217 creator A5089246339 @default.
- W2073168217 date "2006-08-01" @default.
- W2073168217 modified "2023-10-13" @default.
- W2073168217 title "The role of cell cycle regulatory proteins in the pathogenesis of melanoma" @default.
- W2073168217 cites W1492304029 @default.
- W2073168217 cites W1504632294 @default.
- W2073168217 cites W1528955439 @default.
- W2073168217 cites W1635667563 @default.
- W2073168217 cites W1832398459 @default.
- W2073168217 cites W1963763678 @default.
- W2073168217 cites W1964253880 @default.
- W2073168217 cites W1965293485 @default.
- W2073168217 cites W1965573334 @default.
- W2073168217 cites W1966825696 @default.
- W2073168217 cites W1967475743 @default.
- W2073168217 cites W1970779989 @default.
- W2073168217 cites W1970910072 @default.
- W2073168217 cites W1971050728 @default.
- W2073168217 cites W1971512164 @default.
- W2073168217 cites W1972305847 @default.
- W2073168217 cites W1973743622 @default.
- W2073168217 cites W1975324295 @default.
- W2073168217 cites W1978720968 @default.
- W2073168217 cites W1978929236 @default.
- W2073168217 cites W1980890490 @default.
- W2073168217 cites W1981524094 @default.
- W2073168217 cites W1983348452 @default.
- W2073168217 cites W1986541287 @default.
- W2073168217 cites W1987059492 @default.
- W2073168217 cites W1988121733 @default.
- W2073168217 cites W1988907198 @default.
- W2073168217 cites W1989521497 @default.
- W2073168217 cites W1989648702 @default.
- W2073168217 cites W1990743609 @default.
- W2073168217 cites W1992270075 @default.
- W2073168217 cites W1992305792 @default.
- W2073168217 cites W1994455925 @default.
- W2073168217 cites W1994793314 @default.
- W2073168217 cites W1996413533 @default.
- W2073168217 cites W1996545953 @default.
- W2073168217 cites W1997073961 @default.
- W2073168217 cites W1997975397 @default.
- W2073168217 cites W1999330214 @default.
- W2073168217 cites W1999369364 @default.
- W2073168217 cites W1999502149 @default.
- W2073168217 cites W2000292536 @default.
- W2073168217 cites W2003133121 @default.
- W2073168217 cites W2003614944 @default.
- W2073168217 cites W2003920155 @default.
- W2073168217 cites W2006328025 @default.
- W2073168217 cites W2008456937 @default.
- W2073168217 cites W2010240655 @default.
- W2073168217 cites W2011539476 @default.
- W2073168217 cites W2012053348 @default.
- W2073168217 cites W2015169372 @default.
- W2073168217 cites W2015446431 @default.
- W2073168217 cites W2015519364 @default.
- W2073168217 cites W2016225503 @default.
- W2073168217 cites W2016508329 @default.
- W2073168217 cites W2017791020 @default.
- W2073168217 cites W2019903459 @default.
- W2073168217 cites W2020229579 @default.
- W2073168217 cites W2022122800 @default.
- W2073168217 cites W2023199092 @default.
- W2073168217 cites W2025488549 @default.
- W2073168217 cites W2025982955 @default.
- W2073168217 cites W2027482159 @default.
- W2073168217 cites W2027547124 @default.
- W2073168217 cites W2027882268 @default.
- W2073168217 cites W2029080338 @default.
- W2073168217 cites W2031895416 @default.
- W2073168217 cites W2032413267 @default.
- W2073168217 cites W2032477326 @default.
- W2073168217 cites W2036817346 @default.
- W2073168217 cites W2038440122 @default.
- W2073168217 cites W2038500217 @default.
- W2073168217 cites W2039627657 @default.
- W2073168217 cites W2040687166 @default.
- W2073168217 cites W2040876807 @default.
- W2073168217 cites W2041573061 @default.
- W2073168217 cites W2041660810 @default.
- W2073168217 cites W2041827979 @default.
- W2073168217 cites W2041966690 @default.
- W2073168217 cites W2042041600 @default.
- W2073168217 cites W2043070535 @default.
- W2073168217 cites W2043178719 @default.
- W2073168217 cites W2044215244 @default.
- W2073168217 cites W2046072152 @default.
- W2073168217 cites W2046986238 @default.