Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073173679> ?p ?o ?g. }
- W2073173679 endingPage "251" @default.
- W2073173679 startingPage "238" @default.
- W2073173679 abstract "Methamphetamine (METH) is an illicit drug that causes neurodegenerative effects in humans. In rodents, METH induces apoptosis of striatal glutamic acid decarboxylase (GAD) -containing neurons. This paper provides evidence that METH-induced cell death occurs consequent to interactions of ER stress and mitochondrial death pathways. Specifically, injections of METH are followed by an almost immediate activation of proteases calpain and caspase-12, events consistent with drug-induced ER stress. Involvement of ER stress was further supported by observations of increases in the expression of GRP78/BiP and CHOP. Participation of the mitochondrial pathway was demonstrated by the transition of AIF, smac/DIABLO, and cytochrome c from mitochondrial into cytoplasmic fractions. These changes occur before the apoptosome-associated pro-caspase-9 cleavage. Effector caspases-3 and -6, but not -7, were cleaved with the initial time of caspase-3 activation occurring before caspase 9 cleavage; this suggests possible earlier cleavage of caspase-3 by caspase-12. These events preceded proteolysis of the caspase substrates DFF-45, lamin A, and PARP in nuclear fractions. These findings indicate that METH causes neuronal apoptosis in part via cross-talks between ER- and mitochondria-generated processes, which cause activation of both caspase-dependent and -independent pathways." @default.
- W2073173679 created "2016-06-24" @default.
- W2073173679 creator A5006888475 @default.
- W2073173679 creator A5035465827 @default.
- W2073173679 creator A5043772835 @default.
- W2073173679 creator A5053153606 @default.
- W2073173679 creator A5086040285 @default.
- W2073173679 date "2004-02-01" @default.
- W2073173679 modified "2023-10-12" @default.
- W2073173679 title "Methamphetamine induces neuronal apoptosis via cross‐talks between endoplasmic reticulum and mitochondria‐dependent death cascades" @default.
- W2073173679 cites W1482156052 @default.
- W2073173679 cites W1519250999 @default.
- W2073173679 cites W1522763255 @default.
- W2073173679 cites W1535426243 @default.
- W2073173679 cites W1537243389 @default.
- W2073173679 cites W1540417297 @default.
- W2073173679 cites W1610329392 @default.
- W2073173679 cites W1612119967 @default.
- W2073173679 cites W1644437176 @default.
- W2073173679 cites W1904882776 @default.
- W2073173679 cites W1910685430 @default.
- W2073173679 cites W1959879209 @default.
- W2073173679 cites W1965129342 @default.
- W2073173679 cites W1965732243 @default.
- W2073173679 cites W1967912613 @default.
- W2073173679 cites W1978994032 @default.
- W2073173679 cites W1979947456 @default.
- W2073173679 cites W1980462656 @default.
- W2073173679 cites W1981170688 @default.
- W2073173679 cites W1985339713 @default.
- W2073173679 cites W1987785848 @default.
- W2073173679 cites W1988160201 @default.
- W2073173679 cites W1988949532 @default.
- W2073173679 cites W1991094289 @default.
- W2073173679 cites W1996785364 @default.
- W2073173679 cites W1999349182 @default.
- W2073173679 cites W1999713747 @default.
- W2073173679 cites W2005952891 @default.
- W2073173679 cites W2009627704 @default.
- W2073173679 cites W2013065884 @default.
- W2073173679 cites W2014488168 @default.
- W2073173679 cites W2017067141 @default.
- W2073173679 cites W2017102177 @default.
- W2073173679 cites W2017165365 @default.
- W2073173679 cites W2021360005 @default.
- W2073173679 cites W2022889787 @default.
- W2073173679 cites W2023590101 @default.
- W2073173679 cites W2024437197 @default.
- W2073173679 cites W2029183246 @default.
- W2073173679 cites W2036898191 @default.
- W2073173679 cites W2038055601 @default.
- W2073173679 cites W2038295594 @default.
- W2073173679 cites W2040123458 @default.
- W2073173679 cites W2041207883 @default.
- W2073173679 cites W2041424269 @default.
- W2073173679 cites W2042409437 @default.
- W2073173679 cites W2043313694 @default.
- W2073173679 cites W2049876394 @default.
- W2073173679 cites W2050219143 @default.
- W2073173679 cites W2052615494 @default.
- W2073173679 cites W2053264627 @default.
- W2073173679 cites W2053603817 @default.
- W2073173679 cites W2061952598 @default.
- W2073173679 cites W2064164996 @default.
- W2073173679 cites W2066790627 @default.
- W2073173679 cites W2067011924 @default.
- W2073173679 cites W2069924169 @default.
- W2073173679 cites W2070102230 @default.
- W2073173679 cites W2070920868 @default.
- W2073173679 cites W2074430974 @default.
- W2073173679 cites W2078660236 @default.
- W2073173679 cites W2078762001 @default.
- W2073173679 cites W2078849576 @default.
- W2073173679 cites W2080253613 @default.
- W2073173679 cites W2083351059 @default.
- W2073173679 cites W2084240094 @default.
- W2073173679 cites W2084498285 @default.
- W2073173679 cites W2085351407 @default.
- W2073173679 cites W2087693218 @default.
- W2073173679 cites W2090982295 @default.
- W2073173679 cites W2092246706 @default.
- W2073173679 cites W2094155854 @default.
- W2073173679 cites W2100347985 @default.
- W2073173679 cites W2101963635 @default.
- W2073173679 cites W2106287416 @default.
- W2073173679 cites W2111853402 @default.
- W2073173679 cites W2113999599 @default.
- W2073173679 cites W2116334147 @default.
- W2073173679 cites W2119683782 @default.
- W2073173679 cites W2120077675 @default.
- W2073173679 cites W2121898255 @default.
- W2073173679 cites W2125784520 @default.
- W2073173679 cites W2133232851 @default.
- W2073173679 cites W2133589858 @default.
- W2073173679 cites W2134738066 @default.
- W2073173679 cites W2138281508 @default.
- W2073173679 cites W2139290875 @default.
- W2073173679 cites W2139410513 @default.