Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073175195> ?p ?o ?g. }
- W2073175195 endingPage "7" @default.
- W2073175195 startingPage "1" @default.
- W2073175195 abstract "Parenterally administered human recombinant type I interferons (hrIFN) in relapsing-remitting multiple sclerosis (RRMS) decrease relapses and spontaneous in vitro IFN-gamma production, reduce clinical progression, and decrease magnetic resonance imaging (MRI)-defined disease activity and lesions. Parenterally administered type I IFN use is limited by clinical and chemical toxicities, and the induction of antibodies that abrogate their activity in vivo correlated with the loss of clinical benefit. Therefore, we determined whether ingested IFN-alpha was non-toxic and had biological effects in humans. Ingested hrIFN-alpha showed no toxicity in normal volunteers or patients with RRMS at doses ranging from 300 to 100,000 units. In subjects with RRMS, a significant decrease in Con A-mediated proliferation and serum soluble intercellular adhesion molecule-1 (sICAM-1), a surrogate measure for disease activity in MS, was found after ingesting 10,000 and 30,000 units IFN-alpha The RRMS subjects also showed decreased IL-2 secretion after ingesting 10,000 units IFN-alpha and decreased IFN-gamma, TGF-beta and IL-10 production after ingesting 30,000 units IFN-alpha. The decreased secretion of IFN-gamma and IL-2 by ingested IFN-alpha suggests that oral IFN-alpha may cause a functional inhibition of Th J-like T helper cells in RRMS, a potential site of intervention at the level of effector T cells in MS. Our studies support the oral use of human IFN-alpha as a biological response modifier in humans." @default.
- W2073175195 created "2016-06-24" @default.
- W2073175195 creator A5011937918 @default.
- W2073175195 creator A5015522318 @default.
- W2073175195 creator A5019040338 @default.
- W2073175195 creator A5019199875 @default.
- W2073175195 creator A5037222606 @default.
- W2073175195 creator A5039468195 @default.
- W2073175195 creator A5076338840 @default.
- W2073175195 creator A5082016347 @default.
- W2073175195 date "1997-02-01" @default.
- W2073175195 modified "2023-10-06" @default.
- W2073175195 title "Ingested IFN-α has biological effects in humans with relapsing-remitting multiple sclerosis" @default.
- W2073175195 cites W1518310332 @default.
- W2073175195 cites W1564722620 @default.
- W2073175195 cites W1593898429 @default.
- W2073175195 cites W1615621128 @default.
- W2073175195 cites W1657567895 @default.
- W2073175195 cites W1853022482 @default.
- W2073175195 cites W1942668068 @default.
- W2073175195 cites W1972725262 @default.
- W2073175195 cites W1978345766 @default.
- W2073175195 cites W1979799829 @default.
- W2073175195 cites W1992145267 @default.
- W2073175195 cites W1992731033 @default.
- W2073175195 cites W1994251899 @default.
- W2073175195 cites W2000179253 @default.
- W2073175195 cites W2012270273 @default.
- W2073175195 cites W2031253497 @default.
- W2073175195 cites W2032684127 @default.
- W2073175195 cites W2040976924 @default.
- W2073175195 cites W2041391189 @default.
- W2073175195 cites W2060926084 @default.
- W2073175195 cites W2061654508 @default.
- W2073175195 cites W2065036147 @default.
- W2073175195 cites W2065289322 @default.
- W2073175195 cites W2067729006 @default.
- W2073175195 cites W2075942059 @default.
- W2073175195 cites W2081350964 @default.
- W2073175195 cites W2084075700 @default.
- W2073175195 cites W2101771134 @default.
- W2073175195 cites W2104112797 @default.
- W2073175195 cites W2110307088 @default.
- W2073175195 cites W2130355701 @default.
- W2073175195 cites W2165547142 @default.
- W2073175195 cites W2317030287 @default.
- W2073175195 cites W2330910817 @default.
- W2073175195 cites W2485483395 @default.
- W2073175195 cites W4231581694 @default.
- W2073175195 cites W4234254101 @default.
- W2073175195 doi "https://doi.org/10.1177/135245859700300101" @default.
- W2073175195 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9160341" @default.
- W2073175195 hasPublicationYear "1997" @default.
- W2073175195 type Work @default.
- W2073175195 sameAs 2073175195 @default.
- W2073175195 citedByCount "41" @default.
- W2073175195 countsByYear W20731751952014 @default.
- W2073175195 countsByYear W20731751952015 @default.
- W2073175195 countsByYear W20731751952016 @default.
- W2073175195 countsByYear W20731751952023 @default.
- W2073175195 crossrefType "journal-article" @default.
- W2073175195 hasAuthorship W2073175195A5011937918 @default.
- W2073175195 hasAuthorship W2073175195A5015522318 @default.
- W2073175195 hasAuthorship W2073175195A5019040338 @default.
- W2073175195 hasAuthorship W2073175195A5019199875 @default.
- W2073175195 hasAuthorship W2073175195A5037222606 @default.
- W2073175195 hasAuthorship W2073175195A5039468195 @default.
- W2073175195 hasAuthorship W2073175195A5076338840 @default.
- W2073175195 hasAuthorship W2073175195A5082016347 @default.
- W2073175195 hasConcept C126322002 @default.
- W2073175195 hasConcept C141071460 @default.
- W2073175195 hasConcept C150903083 @default.
- W2073175195 hasConcept C203014093 @default.
- W2073175195 hasConcept C207001950 @default.
- W2073175195 hasConcept C2775944032 @default.
- W2073175195 hasConcept C2778690821 @default.
- W2073175195 hasConcept C2780640218 @default.
- W2073175195 hasConcept C2780841837 @default.
- W2073175195 hasConcept C29730261 @default.
- W2073175195 hasConcept C49453240 @default.
- W2073175195 hasConcept C64943373 @default.
- W2073175195 hasConcept C71924100 @default.
- W2073175195 hasConcept C86803240 @default.
- W2073175195 hasConcept C98274493 @default.
- W2073175195 hasConceptScore W2073175195C126322002 @default.
- W2073175195 hasConceptScore W2073175195C141071460 @default.
- W2073175195 hasConceptScore W2073175195C150903083 @default.
- W2073175195 hasConceptScore W2073175195C203014093 @default.
- W2073175195 hasConceptScore W2073175195C207001950 @default.
- W2073175195 hasConceptScore W2073175195C2775944032 @default.
- W2073175195 hasConceptScore W2073175195C2778690821 @default.
- W2073175195 hasConceptScore W2073175195C2780640218 @default.
- W2073175195 hasConceptScore W2073175195C2780841837 @default.
- W2073175195 hasConceptScore W2073175195C29730261 @default.
- W2073175195 hasConceptScore W2073175195C49453240 @default.
- W2073175195 hasConceptScore W2073175195C64943373 @default.
- W2073175195 hasConceptScore W2073175195C71924100 @default.
- W2073175195 hasConceptScore W2073175195C86803240 @default.