FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073175940> ?p ?o ?g. }

• W2073175940 endingPage "88" @default.
• W2073175940 startingPage "79" @default.
• W2073175940 abstract "Poly(methacrylic acid) (PMAA) and related copolymers strongly interact with poly(ethylene glycol) (PEG) in acidic fluids. Due to the in vitro experiments presented in this paper, there is a clear indication for a drug-drug interaction in vivo between PEG solutions, e.g., commercially available laxatives, and dosage forms with PMAA-based enteric-coatings (Eudragit L). In these studies, enteric-coated tablets did not fulfil the pharmacopoeias' criteria of the disintegration test if PEGs were present in the simulated gastric juice. Drug substances which are known to be unstable in acidic media or which can cause gastric irritation were released from their enteric-coated dosage forms in acidic PEG media (pH 1). Various drug dosage forms, single and multiple unit systems, were tested. They show higher and faster drug release in the presence of PEG. To get insight into the mechanism of the interaction, experiments and theoretical calculations were performed which reveal that PEGs with high molecular weight show stronger interactions with PMAA coatings indicating a contribution of hydrophobic interactions to the occurring intermolecular forces. Hydrogen bonds can be build between each monomeric unit of PEG and the acidic sequences of the copolymer." @default.
• W2073175940 created "2016-06-24" @default.
• W2073175940 creator A5065080932 @default.
• W2073175940 date "2000-06-01" @default.
• W2073175940 modified "2023-09-23" @default.
• W2073175940 title "Leakage of enteric (Eudragit® L)-coated dosage forms in simulated gastric juice in the presence of poly(ethylene glycol)" @default.
• W2073175940 cites W18839867 @default.
• W2073175940 cites W1986277903 @default.
• W2073175940 cites W1986770476 @default.
• W2073175940 cites W2009325001 @default.
• W2073175940 cites W2020529817 @default.
• W2073175940 cites W2031195045 @default.
• W2073175940 cites W2038057682 @default.
• W2073175940 cites W2045427758 @default.
• W2073175940 cites W2053701609 @default.
• W2073175940 cites W2060044832 @default.
• W2073175940 cites W2076122139 @default.
• W2073175940 cites W2095502385 @default.
• W2073175940 cites W2105816849 @default.
• W2073175940 cites W2170010544 @default.
• W2073175940 cites W88552196 @default.
• W2073175940 doi "https://doi.org/10.1016/s0168-3659(00)00197-8" @default.
• W2073175940 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10773331" @default.
• W2073175940 hasPublicationYear "2000" @default.
• W2073175940 type Work @default.
• W2073175940 sameAs 2073175940 @default.
• W2073175940 citedByCount "22" @default.
• W2073175940 countsByYear W20731759402012 @default.
• W2073175940 countsByYear W20731759402013 @default.
• W2073175940 countsByYear W20731759402019 @default.
• W2073175940 crossrefType "journal-article" @default.
• W2073175940 hasAuthorship W2073175940A5065080932 @default.
• W2073175940 hasConcept C10138342 @default.
• W2073175940 hasConcept C112887158 @default.
• W2073175940 hasConcept C13965031 @default.
• W2073175940 hasConcept C150903083 @default.
• W2073175940 hasConcept C15920480 @default.
• W2073175940 hasConcept C162324750 @default.
• W2073175940 hasConcept C166940927 @default.
• W2073175940 hasConcept C166950319 @default.
• W2073175940 hasConcept C178790620 @default.
• W2073175940 hasConcept C185592680 @default.
• W2073175940 hasConcept C207001950 @default.
• W2073175940 hasConcept C2775968528 @default.
• W2073175940 hasConcept C2776964284 @default.
• W2073175940 hasConcept C2777516009 @default.
• W2073175940 hasConcept C2780035454 @default.
• W2073175940 hasConcept C3020346381 @default.
• W2073175940 hasConcept C32909587 @default.
• W2073175940 hasConcept C43617362 @default.
• W2073175940 hasConcept C521977710 @default.
• W2073175940 hasConcept C54400483 @default.
• W2073175940 hasConcept C71924100 @default.
• W2073175940 hasConcept C77281830 @default.
• W2073175940 hasConcept C86803240 @default.
• W2073175940 hasConcept C98274493 @default.
• W2073175940 hasConceptScore W2073175940C10138342 @default.
• W2073175940 hasConceptScore W2073175940C112887158 @default.
• W2073175940 hasConceptScore W2073175940C13965031 @default.
• W2073175940 hasConceptScore W2073175940C150903083 @default.
• W2073175940 hasConceptScore W2073175940C15920480 @default.
• W2073175940 hasConceptScore W2073175940C162324750 @default.
• W2073175940 hasConceptScore W2073175940C166940927 @default.
• W2073175940 hasConceptScore W2073175940C166950319 @default.
• W2073175940 hasConceptScore W2073175940C178790620 @default.
• W2073175940 hasConceptScore W2073175940C185592680 @default.
• W2073175940 hasConceptScore W2073175940C207001950 @default.
• W2073175940 hasConceptScore W2073175940C2775968528 @default.
• W2073175940 hasConceptScore W2073175940C2776964284 @default.
• W2073175940 hasConceptScore W2073175940C2777516009 @default.
• W2073175940 hasConceptScore W2073175940C2780035454 @default.
• W2073175940 hasConceptScore W2073175940C3020346381 @default.
• W2073175940 hasConceptScore W2073175940C32909587 @default.
• W2073175940 hasConceptScore W2073175940C43617362 @default.
• W2073175940 hasConceptScore W2073175940C521977710 @default.
• W2073175940 hasConceptScore W2073175940C54400483 @default.
• W2073175940 hasConceptScore W2073175940C71924100 @default.
• W2073175940 hasConceptScore W2073175940C77281830 @default.
• W2073175940 hasConceptScore W2073175940C86803240 @default.
• W2073175940 hasConceptScore W2073175940C98274493 @default.
• W2073175940 hasIssue "1" @default.
• W2073175940 hasLocation W20731759401 @default.
• W2073175940 hasLocation W20731759402 @default.
• W2073175940 hasOpenAccess W2073175940 @default.
• W2073175940 hasPrimaryLocation W20731759401 @default.
• W2073175940 hasRelatedWork W1969079757 @default.
• W2073175940 hasRelatedWork W2016771022 @default.
• W2073175940 hasRelatedWork W2039258295 @default.
• W2073175940 hasRelatedWork W2044723767 @default.
• W2073175940 hasRelatedWork W2073175940 @default.
• W2073175940 hasRelatedWork W2145501107 @default.
• W2073175940 hasRelatedWork W2376868106 @default.
• W2073175940 hasRelatedWork W2387930247 @default.
• W2073175940 hasRelatedWork W4252436347 @default.
• W2073175940 hasRelatedWork W4254439324 @default.
• W2073175940 hasVolume "67" @default.
• W2073175940 isParatext "false" @default.
• W2073175940 isRetracted "false" @default.

• next