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- W2073175943 abstract "A facile preparation of 3-acyl-substituted isoxazolines, benzisoxazoles, and isoxazoles from the corresponding 3-carboxylate esters is described. The process, involving reaction of the ester derivative of 3-carboxylic acid substituted heterocycles with Grignard or alkynyl lithium reagents, leads to direct generation of the corresponding 3-acyl heterocycle. The presence of α-imino ester moieties in the heterocyclic substrates for the reactions is thought to be a key feature governing the nature of these transformations. The synthetic utility of the new methodology is demonstrated by its application in a two-step route for the preparation of novel linked bis-heterocycles." @default.
- W2073175943 created "2016-06-24" @default.
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- W2073175943 date "2012-07-01" @default.
- W2073175943 modified "2023-10-17" @default.
- W2073175943 title "Reactivity of the ester group attached isoxazoline, benzisoxazole, and isoxazole: a facial preparation of 3-acyl-substituted these heterocycles" @default.
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- W2073175943 doi "https://doi.org/10.1016/j.tetlet.2012.05.006" @default.
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