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• W2073190662 abstract "The regulation of the aldo-keto reductase AKR7A1 was examined in the livers of male and female rats during development by using Western blots, and its contribution to carbonyl metabolism was assessed by using enzyme assays. Hepatic levels of AKR7A1 are low in fetal rats and rise to a peak at around 6 weeks of age in animals of both sexes. Higher levels of the enzyme are found in adult male rat liver than in adult female rat liver. The reductase, therefore, appears to be subject to sex-specific regulation. The effect of growth hormone in mediating this difference in expression was examined by using hypophysectomized animals whose serum growth hormone levels had been feminized by continuous administration. Results demonstrate that such treatment leads to a reduction in AKR7A1 expression. AKR7A1 was found to be constitutively expressed in rat tissues such as liver, kidney, small intestine, and testis, but it was not detected in nasal mucosa, skeletal muscle, heart, adrenal gland, brain, or spleen. However, AKR7A1 was inducible by the synthetic antioxidant ethoxyquin in liver, kidney, and small intestine, but not in the other tissues examined. These results show that levels of this important detoxication enzyme vary considerably according to age and sex and that dietary antioxidants can also influence its level in several tissues." @default.
• W2073190662 created "2016-06-24" @default.
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• W2073190662 date "2001-12-01" @default.
• W2073190662 modified "2023-10-16" @default.
• W2073190662 title "Expression of rat aldehyde reductase AKR7A1: influence of age and sex and tissue-specific inducibility ☆ 1 ☆This work was funded partly by a grant from the Association for International Cancer Research. EME was supported by a Beit Memorial Fellowship and VPK was supported by a Biomedical Research Centre Studentship. The experiments performed in Stockholm were supported by the Knut and Alice Wallenberg Foundation. 1Abbreviations: 2-CBA, 2-carboxybenzaldehyde; 4-NBA, 4-nitrobenzaldehyde; 9,10-PQ…" @default.
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• W2073190662 doi "https://doi.org/10.1016/s0006-2952(01)00771-7" @default.
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