Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073193043> ?p ?o ?g. }
- W2073193043 endingPage "445" @default.
- W2073193043 startingPage "430" @default.
- W2073193043 abstract "Summary Venous thrombosis is more frequent in patients treated for acute lymphoblastic leukaemia (ALL) than other malignancies and has distinctive causes, clinical features and remedies. The reported incidence varies from 1% to 36%, depending on the chemotherapy protocol and whether the reported cases are symptomatic or detected on screening radiography. The risk is thought to arise from increased thrombin generation at diagnosis combined with reduced thrombin inhibitory capacity due to depletion of circulating anti‐thrombin (AT) by asparaginase. A number of patient and treatment variables have been reported to influence the risk of thrombosis including hereditary thrombophilia, early insertion of central venous catheters and exposure to a combination of steroids and asparaginase during induction. Erwinia asparaginase is associated with a lower risk of thrombosis compared with Escherichia coli asparaginase. The majority of symptomatic thromboses are related to central venous catheters and involve the upper venous system. Central nervous system thrombosis involving the cerebral venous sinuses is a unique feature of asparaginase‐related thrombosis and is reported to occur in 1–3% of patients. Conclusive evidence to support the use of anti‐coagulant treatment or AT concentrates for primary prevention is lacking, as is evidence for the efficacy of AT concentrates in the management of established thrombosis. Preventative strategies are hampered by conflicting data on factors that would enable identification of those at highest risk of thrombosis." @default.
- W2073193043 created "2016-06-24" @default.
- W2073193043 creator A5029463363 @default.
- W2073193043 creator A5066319509 @default.
- W2073193043 date "2007-06-29" @default.
- W2073193043 modified "2023-10-17" @default.
- W2073193043 title "Thrombosis and acute lymphoblastic leukaemia" @default.
- W2073193043 cites W133525775 @default.
- W2073193043 cites W135448532 @default.
- W2073193043 cites W1770147359 @default.
- W2073193043 cites W181091954 @default.
- W2073193043 cites W1963785346 @default.
- W2073193043 cites W1972290122 @default.
- W2073193043 cites W1973550803 @default.
- W2073193043 cites W1973771885 @default.
- W2073193043 cites W1974885634 @default.
- W2073193043 cites W1975798368 @default.
- W2073193043 cites W1976677371 @default.
- W2073193043 cites W1977033535 @default.
- W2073193043 cites W1977289046 @default.
- W2073193043 cites W1978342339 @default.
- W2073193043 cites W1978645977 @default.
- W2073193043 cites W1982505387 @default.
- W2073193043 cites W1982933638 @default.
- W2073193043 cites W1985276652 @default.
- W2073193043 cites W1985633272 @default.
- W2073193043 cites W1990750943 @default.
- W2073193043 cites W1993211677 @default.
- W2073193043 cites W1993364948 @default.
- W2073193043 cites W1993893409 @default.
- W2073193043 cites W1998203250 @default.
- W2073193043 cites W1999668293 @default.
- W2073193043 cites W1999820147 @default.
- W2073193043 cites W1999920194 @default.
- W2073193043 cites W2002808378 @default.
- W2073193043 cites W2010064279 @default.
- W2073193043 cites W2010623441 @default.
- W2073193043 cites W2011532906 @default.
- W2073193043 cites W2012808596 @default.
- W2073193043 cites W2014561096 @default.
- W2073193043 cites W2016822528 @default.
- W2073193043 cites W2017709422 @default.
- W2073193043 cites W2022932023 @default.
- W2073193043 cites W2027460583 @default.
- W2073193043 cites W2029975727 @default.
- W2073193043 cites W2034386282 @default.
- W2073193043 cites W2034485178 @default.
- W2073193043 cites W2035427759 @default.
- W2073193043 cites W2035924453 @default.
- W2073193043 cites W2038493852 @default.
- W2073193043 cites W2041054804 @default.
- W2073193043 cites W2043666716 @default.
- W2073193043 cites W2044703058 @default.
- W2073193043 cites W2044889252 @default.
- W2073193043 cites W2048017132 @default.
- W2073193043 cites W2048708519 @default.
- W2073193043 cites W2052321442 @default.
- W2073193043 cites W2055477810 @default.
- W2073193043 cites W2057118034 @default.
- W2073193043 cites W2058862061 @default.
- W2073193043 cites W2059992379 @default.
- W2073193043 cites W2066270116 @default.
- W2073193043 cites W2080318130 @default.
- W2073193043 cites W2085292470 @default.
- W2073193043 cites W2087661939 @default.
- W2073193043 cites W2090476707 @default.
- W2073193043 cites W2092824446 @default.
- W2073193043 cites W2096146076 @default.
- W2073193043 cites W2097682287 @default.
- W2073193043 cites W2103347449 @default.
- W2073193043 cites W2103419160 @default.
- W2073193043 cites W2103664603 @default.
- W2073193043 cites W2107419838 @default.
- W2073193043 cites W2124101267 @default.
- W2073193043 cites W2127153931 @default.
- W2073193043 cites W2130646692 @default.
- W2073193043 cites W2134355273 @default.
- W2073193043 cites W2143907400 @default.
- W2073193043 cites W2147865643 @default.
- W2073193043 cites W2148089614 @default.
- W2073193043 cites W2150036781 @default.
- W2073193043 cites W2162051878 @default.
- W2073193043 cites W2167583660 @default.
- W2073193043 cites W2179538720 @default.
- W2073193043 cites W2181058469 @default.
- W2073193043 cites W2200339106 @default.
- W2073193043 cites W229376883 @default.
- W2073193043 cites W2294639865 @default.
- W2073193043 cites W2341248606 @default.
- W2073193043 cites W2400065648 @default.
- W2073193043 cites W2418138855 @default.
- W2073193043 cites W2418212244 @default.
- W2073193043 cites W2431400592 @default.
- W2073193043 cites W2557704715 @default.
- W2073193043 cites W2980067816 @default.
- W2073193043 cites W4254130855 @default.
- W2073193043 cites W4324114385 @default.
- W2073193043 cites W4366305787 @default.