FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073200313> ?p ?o ?g. }

• W2073200313 endingPage "736" @default.
• W2073200313 startingPage "729" @default.
• W2073200313 abstract "Fatal arrhythmias may be prevented by long-term oral administration of angiotensin-converting enzyme (ACE) inhibitors or angiotensin II type 1 (AT 1 ) receptor antagonists. However, there have been no studies evaluating the electrophysiologic changes that occur with the acute administration of AT 1 receptor antagonists during acute myocardial ischemia and reperfusion. This study aimed to evaluate the ability of candesartan to prevent fatal arrhythmias during acute myocardial ischemia and reperfusion. The left anterior descending (LAD) coronary artery was ligated for 10 min and then reperfused for 10 min in 45 adult mongrel dogs. Candesartan (1 mg/kg) or saline was administered intravenously 10 min before ligation of the LAD coronary artery (candesartan group [n = 20] and control group [n = 25], respectively). Changes in ventricular effective refractory period (ERP) and intramyocardial conduction time (ICT) in the risk area were compared during LAD occlusion and reperfusion. Ischemia-induced shortening of ERP was inhibited in the candesartan group compared with the control. There was a 4.7 +/- 5.8% increase in ERP in the candesartan group, compared with a 11.5 +/- 6.3% shortening in the control group (p < 0.01). Prolongation of ICT was inhibited in the candesartan group compared with the control group during both ischemia and reperfusion (maximal prolongation of ICT: 0.1 +/- 3.0% vs. 37.7 +/- 9.6%, respectively; p < 0.01). Incidence of ventricular fibrillation was lower in the candesartan group than in the control group (25% [5/20] vs. 72% [18/25], respectively; p < 0.01). Candesartan suppresses changes in ERP and ICT during acute myocardial ischemia and reperfusion, suggesting that candesartan can prevent the development of fatal arrhythmias." @default.
• W2073200313 created "2016-06-24" @default.
• W2073200313 creator A5002936829 @default.
• W2073200313 creator A5049933159 @default.
• W2073200313 creator A5058999827 @default.
• W2073200313 creator A5064667035 @default.
• W2073200313 creator A5078140561 @default.
• W2073200313 creator A5078886395 @default.
• W2073200313 date "2001-11-01" @default.
• W2073200313 modified "2023-10-14" @default.
• W2073200313 title "Effects of Angiotensin II Type 1 Receptor Antagonist (Candesartan) in Preventing Fatal Ventricular Arrhythmias in Dogs during Acute Myocardial Ischemia and Reperfusion" @default.
• W2073200313 cites W1523320493 @default.
• W2073200313 cites W1712512316 @default.
• W2073200313 cites W1968111298 @default.
• W2073200313 cites W1980653777 @default.
• W2073200313 cites W1992091373 @default.
• W2073200313 cites W1994886734 @default.
• W2073200313 cites W1994931030 @default.
• W2073200313 cites W2010258535 @default.
• W2073200313 cites W2012444504 @default.
• W2073200313 cites W2024162107 @default.
• W2073200313 cites W2029828949 @default.
• W2073200313 cites W2039490249 @default.
• W2073200313 cites W2047089949 @default.
• W2073200313 cites W2054128402 @default.
• W2073200313 cites W2054294711 @default.
• W2073200313 cites W2059746125 @default.
• W2073200313 cites W2065085511 @default.
• W2073200313 cites W2072652433 @default.
• W2073200313 cites W2082462448 @default.
• W2073200313 cites W2086686449 @default.
• W2073200313 cites W2087494973 @default.
• W2073200313 cites W2099446248 @default.
• W2073200313 cites W2099601272 @default.
• W2073200313 cites W2104862794 @default.
• W2073200313 cites W2148259536 @default.
• W2073200313 cites W2312388685 @default.
• W2073200313 cites W2407589615 @default.
• W2073200313 cites W2473573051 @default.
• W2073200313 cites W2895806954 @default.
• W2073200313 cites W4245244523 @default.
• W2073200313 cites W4254488429 @default.
• W2073200313 cites W2035998030 @default.
• W2073200313 doi "https://doi.org/10.1097/00005344-200111000-00009" @default.
• W2073200313 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11602819" @default.
• W2073200313 hasPublicationYear "2001" @default.
• W2073200313 type Work @default.
• W2073200313 sameAs 2073200313 @default.
• W2073200313 citedByCount "6" @default.
• W2073200313 countsByYear W20732003132012 @default.
• W2073200313 crossrefType "journal-article" @default.
• W2073200313 hasAuthorship W2073200313A5002936829 @default.
• W2073200313 hasAuthorship W2073200313A5049933159 @default.
• W2073200313 hasAuthorship W2073200313A5058999827 @default.
• W2073200313 hasAuthorship W2073200313A5064667035 @default.
• W2073200313 hasAuthorship W2073200313A5078140561 @default.
• W2073200313 hasAuthorship W2073200313A5078886395 @default.
• W2073200313 hasBestOaLocation W20732003131 @default.
• W2073200313 hasConcept C126322002 @default.
• W2073200313 hasConcept C164705383 @default.
• W2073200313 hasConcept C170493617 @default.
• W2073200313 hasConcept C2780036600 @default.
• W2073200313 hasConcept C2781005686 @default.
• W2073200313 hasConcept C2908929049 @default.
• W2073200313 hasConcept C42219234 @default.
• W2073200313 hasConcept C541997718 @default.
• W2073200313 hasConcept C71924100 @default.
• W2073200313 hasConceptScore W2073200313C126322002 @default.
• W2073200313 hasConceptScore W2073200313C164705383 @default.
• W2073200313 hasConceptScore W2073200313C170493617 @default.
• W2073200313 hasConceptScore W2073200313C2780036600 @default.
• W2073200313 hasConceptScore W2073200313C2781005686 @default.
• W2073200313 hasConceptScore W2073200313C2908929049 @default.
• W2073200313 hasConceptScore W2073200313C42219234 @default.
• W2073200313 hasConceptScore W2073200313C541997718 @default.
• W2073200313 hasConceptScore W2073200313C71924100 @default.
• W2073200313 hasIssue "5" @default.
• W2073200313 hasLocation W20732003131 @default.
• W2073200313 hasLocation W20732003132 @default.
• W2073200313 hasLocation W20732003133 @default.
• W2073200313 hasOpenAccess W2073200313 @default.
• W2073200313 hasPrimaryLocation W20732003131 @default.
• W2073200313 hasRelatedWork W1978722589 @default.
• W2073200313 hasRelatedWork W1990044643 @default.
• W2073200313 hasRelatedWork W1994501076 @default.
• W2073200313 hasRelatedWork W2066226598 @default.
• W2073200313 hasRelatedWork W2101703532 @default.
• W2073200313 hasRelatedWork W2109896298 @default.
• W2073200313 hasRelatedWork W2131490392 @default.
• W2073200313 hasRelatedWork W2171797634 @default.
• W2073200313 hasRelatedWork W2753862020 @default.
• W2073200313 hasRelatedWork W4301156385 @default.
• W2073200313 hasVolume "38" @default.
• W2073200313 isParatext "false" @default.
• W2073200313 isRetracted "false" @default.
• W2073200313 magId "2073200313" @default.
• W2073200313 workType "article" @default.