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• W2073200352 abstract "Biporous (macro- and microporous) calcium phosphate gains much attention as a bone substitute material because of its large surface area and that it improves cell penetration. In the present study, we evaluated the feasibility of biporous, low-crystalline apatite based on dissolution of mannitol from self-setting apatite cement (Biopex). Mannitol--known as a biocompatible, easily dissolved monosaccharide alcohol--was recrystallized to obtain larger crystals. It was crushed with pestle and mortar, sieved to obtain crystals which passed through a 500-microm mesh but which remained against a 300-microm mesh, and then used as porogen. Although Biopex containing 60 wt% mannitol was not able to be taken out of the mold, addition of mannitol caused no initial setting inhibition to Biopex if the amount was 40 wt% or less. Similarly, transformation to apatitic product was confirmed when the apatite cement was immersed in 0.9% saline kept at 37 degrees C for seven days. The set mass became low-crystalline, biporous apatite with approximately 60% porosity." @default.
• W2073200352 created "2016-06-24" @default.
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• W2073200352 date "2006-01-01" @default.
• W2073200352 modified "2023-10-01" @default.
• W2073200352 title "Fabrication of Biporous Low-crystalline Apatite Based on Mannitol Dissolution from Apatite Cement" @default.
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• W2073200352 doi "https://doi.org/10.4012/dmj.25.616" @default.
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