Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073204295> ?p ?o ?g. }
- W2073204295 endingPage "957" @default.
- W2073204295 startingPage "951" @default.
- W2073204295 abstract "During the first trimester of pregnancy the human placenta develops in an hypoxic environment caused by the occlusion of uterine spiral arterioles by extravillous trophoblasts (EVT). This period of low oxygen tension is crucial for successful pregnancy. In low oxygen environments, Hypoxia Inducible Factors (HIF) are the main regulators in the transcription of a number of genes. Target genes can induce anaerobic processes, reducing oxygen consumption, or promote angiogenesis, which establishes and enhances the vascular environment. The HIFs can function throughout all stages of placental differentiation and growth both in normal and pathological pregnancies (compromised by hypoxia/ischemia). Interestingly, HIFs respond to a multitude of changes during pregnancy, including 1) low oxygen, 2) renin–angiotensin system (RAS), 3) cytokines, and 4) growth factors, all of which regulate placental function. This review explores oxygen-dependent and oxygen-independent regulation and the role of HIF in placental development and differentiation." @default.
- W2073204295 created "2016-06-24" @default.
- W2073204295 creator A5015422558 @default.
- W2073204295 creator A5044696095 @default.
- W2073204295 creator A5053184115 @default.
- W2073204295 creator A5058423993 @default.
- W2073204295 date "2010-11-01" @default.
- W2073204295 modified "2023-09-24" @default.
- W2073204295 title "Regulation of Hypoxia Inducible Factors (HIF) in Hypoxia and Normoxia During Placental Development" @default.
- W2073204295 cites W1595866873 @default.
- W2073204295 cites W1709785272 @default.
- W2073204295 cites W171819190 @default.
- W2073204295 cites W1911418737 @default.
- W2073204295 cites W1970351535 @default.
- W2073204295 cites W1972443534 @default.
- W2073204295 cites W1978206983 @default.
- W2073204295 cites W1984405338 @default.
- W2073204295 cites W1984849627 @default.
- W2073204295 cites W1986014993 @default.
- W2073204295 cites W1986469266 @default.
- W2073204295 cites W1988338105 @default.
- W2073204295 cites W1993234733 @default.
- W2073204295 cites W1993274418 @default.
- W2073204295 cites W1997109446 @default.
- W2073204295 cites W1999204839 @default.
- W2073204295 cites W1999967082 @default.
- W2073204295 cites W2011758614 @default.
- W2073204295 cites W2016287341 @default.
- W2073204295 cites W2016484560 @default.
- W2073204295 cites W2019759067 @default.
- W2073204295 cites W2020953798 @default.
- W2073204295 cites W2024318861 @default.
- W2073204295 cites W2026329673 @default.
- W2073204295 cites W2028842500 @default.
- W2073204295 cites W2029058414 @default.
- W2073204295 cites W2029627701 @default.
- W2073204295 cites W2030918859 @default.
- W2073204295 cites W2031248838 @default.
- W2073204295 cites W2040031153 @default.
- W2073204295 cites W2048216460 @default.
- W2073204295 cites W2055386292 @default.
- W2073204295 cites W2060989584 @default.
- W2073204295 cites W2064178384 @default.
- W2073204295 cites W2064540829 @default.
- W2073204295 cites W2068754779 @default.
- W2073204295 cites W2072177711 @default.
- W2073204295 cites W2073371406 @default.
- W2073204295 cites W2074824347 @default.
- W2073204295 cites W2080149436 @default.
- W2073204295 cites W2081871156 @default.
- W2073204295 cites W2084550294 @default.
- W2073204295 cites W2089221056 @default.
- W2073204295 cites W2089611230 @default.
- W2073204295 cites W2093776019 @default.
- W2073204295 cites W2097321304 @default.
- W2073204295 cites W2102277066 @default.
- W2073204295 cites W2103214055 @default.
- W2073204295 cites W2107652077 @default.
- W2073204295 cites W2108548188 @default.
- W2073204295 cites W2108847326 @default.
- W2073204295 cites W2112769664 @default.
- W2073204295 cites W2114519926 @default.
- W2073204295 cites W2119084006 @default.
- W2073204295 cites W2137262465 @default.
- W2073204295 cites W2139843241 @default.
- W2073204295 cites W2143180984 @default.
- W2073204295 cites W2143514744 @default.
- W2073204295 cites W2144625075 @default.
- W2073204295 cites W2148950320 @default.
- W2073204295 cites W2149962573 @default.
- W2073204295 cites W2151389745 @default.
- W2073204295 cites W2154412334 @default.
- W2073204295 cites W2156781849 @default.
- W2073204295 cites W2156808865 @default.
- W2073204295 cites W2165523086 @default.
- W2073204295 cites W2167473316 @default.
- W2073204295 cites W2169892373 @default.
- W2073204295 cites W2169962011 @default.
- W2073204295 cites W4234043674 @default.
- W2073204295 cites W4244190676 @default.
- W2073204295 cites W4247114438 @default.
- W2073204295 cites W4297900680 @default.
- W2073204295 doi "https://doi.org/10.1016/j.placenta.2010.08.008" @default.
- W2073204295 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20869770" @default.
- W2073204295 hasPublicationYear "2010" @default.
- W2073204295 type Work @default.
- W2073204295 sameAs 2073204295 @default.
- W2073204295 citedByCount "128" @default.
- W2073204295 countsByYear W20732042952012 @default.
- W2073204295 countsByYear W20732042952013 @default.
- W2073204295 countsByYear W20732042952014 @default.
- W2073204295 countsByYear W20732042952015 @default.
- W2073204295 countsByYear W20732042952016 @default.
- W2073204295 countsByYear W20732042952017 @default.
- W2073204295 countsByYear W20732042952018 @default.
- W2073204295 countsByYear W20732042952019 @default.
- W2073204295 countsByYear W20732042952020 @default.
- W2073204295 countsByYear W20732042952021 @default.