FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073207312> ?p ?o ?g. }

• W2073207312 endingPage "5190" @default.
• W2073207312 startingPage "5179" @default.
• W2073207312 abstract "In Caenorhabditis elegans, the identification of many enzymes involved in the synthesis and modification of glycosaminoglycans (GAGs), essential components of proteoglycans, has attained special attention in recent years. Mutations in all the genes that encode for GAG biosynthetic enzymes show defects in the development of the vulva, specifically in the invagination of the vulval epithelium. Mutants for certain heparan sulfate modifying enzymes present axonal and cellular guidance defects in specific neuronal classes. Although most of the enzymes involved in the biosynthesis and modification of heparan sulfate have been characterized in C. elegans, little is known regarding the core proteins to which these GAGs covalently bind in proteoglycans. A single syndecan homologue (sdn-1) has been identified in the C. elegans genome through sequence analysis. In the present study, we show that C. elegans synthesizes sulfated proteoglycans, seen as three distinct species in western blot analysis. In the sdn-1 (ok449) deletion mutant allele we observed the lack of one species, which corresponds to a 50 kDa product after heparitinase treatment. The expression of sdn-1 mRNA and sequencing revealed that sdn-1 (ok449) deletion mutants lack two glycosylation sites. Hence, the missing protein in the western blot analysis probably corresponds to SDN-1. In addition, we show that SDN-1 localizes to the C. elegans nerve ring, nerve cords and to the vulva. SDN-1 is found specifically phosphorylated in nerve ring neurons and in the vulva, in both wild-type worms and sdn-1 (ok449) deletion mutants. These mutants show a defective egg-laying phenotype. Our results show for the first time, the identification, localization and some functional aspects of syndecan in the nematode C. elegans." @default.
• W2073207312 created "2016-06-24" @default.
• W2073207312 creator A5012719615 @default.
• W2073207312 creator A5041362330 @default.
• W2073207312 creator A5053173891 @default.
• W2073207312 creator A5091641475 @default.
• W2073207312 date "2004-10-01" @default.
• W2073207312 modified "2023-09-23" @default.
• W2073207312 title "<i>Caenorhabditis elegans</i> syndecan (SDN-1) is required for normal egg laying and associates with the nervous system and the vulva" @default.
• W2073207312 cites W1483504657 @default.
• W2073207312 cites W1506210994 @default.
• W2073207312 cites W1853807720 @default.
• W2073207312 cites W1913314522 @default.
• W2073207312 cites W1944127002 @default.
• W2073207312 cites W1966992892 @default.
• W2073207312 cites W1974604649 @default.
• W2073207312 cites W1975601614 @default.
• W2073207312 cites W1990295810 @default.
• W2073207312 cites W1993608710 @default.
• W2073207312 cites W1999279952 @default.
• W2073207312 cites W2006030363 @default.
• W2073207312 cites W2011166758 @default.
• W2073207312 cites W2017156935 @default.
• W2073207312 cites W2021655573 @default.
• W2073207312 cites W2025219025 @default.
• W2073207312 cites W2031143008 @default.
• W2073207312 cites W2032977152 @default.
• W2073207312 cites W2046386872 @default.
• W2073207312 cites W2046910246 @default.
• W2073207312 cites W2047329075 @default.
• W2073207312 cites W2051270234 @default.
• W2073207312 cites W2051440844 @default.
• W2073207312 cites W2053092498 @default.
• W2073207312 cites W2053811100 @default.
• W2073207312 cites W2053902089 @default.
• W2073207312 cites W2058825541 @default.
• W2073207312 cites W2066538250 @default.
• W2073207312 cites W2069935884 @default.
• W2073207312 cites W2076669421 @default.
• W2073207312 cites W2078622143 @default.
• W2073207312 cites W2080559953 @default.
• W2073207312 cites W2087336633 @default.
• W2073207312 cites W2089810290 @default.
• W2073207312 cites W2092852694 @default.
• W2073207312 cites W2096302461 @default.
• W2073207312 cites W2097642025 @default.
• W2073207312 cites W2110779290 @default.
• W2073207312 cites W2113936637 @default.
• W2073207312 cites W2141002604 @default.
• W2073207312 cites W2143621104 @default.
• W2073207312 cites W2143890380 @default.
• W2073207312 cites W2169829977 @default.
• W2073207312 cites W316690497 @default.
• W2073207312 doi "https://doi.org/10.1242/jcs.01394" @default.
• W2073207312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15456854" @default.
• W2073207312 hasPublicationYear "2004" @default.
• W2073207312 type Work @default.
• W2073207312 sameAs 2073207312 @default.
• W2073207312 citedByCount "50" @default.
• W2073207312 countsByYear W20732073122013 @default.
• W2073207312 countsByYear W20732073122014 @default.
• W2073207312 countsByYear W20732073122015 @default.
• W2073207312 countsByYear W20732073122016 @default.
• W2073207312 countsByYear W20732073122017 @default.
• W2073207312 countsByYear W20732073122020 @default.
• W2073207312 countsByYear W20732073122021 @default.
• W2073207312 countsByYear W20732073122022 @default.
• W2073207312 crossrefType "journal-article" @default.
• W2073207312 hasAuthorship W2073207312A5012719615 @default.
• W2073207312 hasAuthorship W2073207312A5041362330 @default.
• W2073207312 hasAuthorship W2073207312A5053173891 @default.
• W2073207312 hasAuthorship W2073207312A5091641475 @default.
• W2073207312 hasConcept C104317684 @default.
• W2073207312 hasConcept C127716648 @default.
• W2073207312 hasConcept C143065580 @default.
• W2073207312 hasConcept C1491633281 @default.
• W2073207312 hasConcept C153074725 @default.
• W2073207312 hasConcept C2776415932 @default.
• W2073207312 hasConcept C2778041096 @default.
• W2073207312 hasConcept C2778944004 @default.
• W2073207312 hasConcept C2779530196 @default.
• W2073207312 hasConcept C54355233 @default.
• W2073207312 hasConcept C55493867 @default.
• W2073207312 hasConcept C65001120 @default.
• W2073207312 hasConcept C69125201 @default.
• W2073207312 hasConcept C86803240 @default.
• W2073207312 hasConcept C95444343 @default.
• W2073207312 hasConceptScore W2073207312C104317684 @default.
• W2073207312 hasConceptScore W2073207312C127716648 @default.
• W2073207312 hasConceptScore W2073207312C143065580 @default.
• W2073207312 hasConceptScore W2073207312C1491633281 @default.
• W2073207312 hasConceptScore W2073207312C153074725 @default.
• W2073207312 hasConceptScore W2073207312C2776415932 @default.
• W2073207312 hasConceptScore W2073207312C2778041096 @default.
• W2073207312 hasConceptScore W2073207312C2778944004 @default.
• W2073207312 hasConceptScore W2073207312C2779530196 @default.
• W2073207312 hasConceptScore W2073207312C54355233 @default.
• W2073207312 hasConceptScore W2073207312C55493867 @default.

• next