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• W2073207703 abstract "Studies on infection-induced inflammatory reactions in humans rely largely on findings in the blood compartment. Peritoneal leukocytes from patients treated with peritoneal dialysis offer a unique opportunity to study in humans the inflammatory responses taking place at the site of infection. Compared with peritoneal macrophages (pM<svg style=vertical-align:-2.29482pt;width:10.2px; id=M1 height=13.425 version=1.1 viewBox=0 0 10.2 13.425 width=10.2 xmlns=http://www.w3.org/2000/svg> <g transform=matrix(1.25,0,0,-1.25,0,13.425)> <g transform=translate(72,-61.26)> <text transform=matrix(1,0,0,-1,-71.95,63.6)> <tspan style=font-size: 12.50px; x=0 y=0>𝜙</tspan> </text> </g> </g> </svg>) from uninfected patients, pM<svg style=vertical-align:-2.29482pt;width:10.2px; id=M2 height=13.425 version=1.1 viewBox=0 0 10.2 13.425 width=10.2 xmlns=http://www.w3.org/2000/svg> <g transform=matrix(1.25,0,0,-1.25,0,13.425)> <g transform=translate(72,-61.26)> <text transform=matrix(1,0,0,-1,-71.95,63.6)> <tspan style=font-size: 12.50px; x=0 y=0>𝜙</tspan> </text> </g> </g> </svg> from infected patients display <i>ex vivo</i> an upregulation and downregulation of proinflammatory and anti-inflammatory mediators, respectively. Pro-IL-1<svg style=vertical-align:-2.29482pt;width:8.8500004px; id=M3 height=13.425 version=1.1 viewBox=0 0 8.8500004 13.425 width=8.8500004 xmlns=http://www.w3.org/2000/svg> <g transform=matrix(1.25,0,0,-1.25,0,13.425)> <g transform=translate(72,-61.26)> <text transform=matrix(1,0,0,-1,-71.95,63.6)> <tspan style=font-size: 12.50px; x=0 y=0>𝛽</tspan> </text> </g> </g> </svg> processing and secretion rather than synthesis proves to be increased in pM<svg style=vertical-align:-2.29482pt;width:10.2px; id=M4 height=13.425 version=1.1 viewBox=0 0 10.2 13.425 width=10.2 xmlns=http://www.w3.org/2000/svg> <g transform=matrix(1.25,0,0,-1.25,0,13.425)> <g transform=translate(72,-61.26)> <text transform=matrix(1,0,0,-1,-71.95,63.6)> <tspan style=font-size: 12.50px; x=0 y=0>𝜙</tspan> </text> </g> </g> </svg> from infectious peritonitis suggesting up-regulation of caspase-1 <i >in vivo</i>. A crosstalk between pM<svg style=vertical-align:-2.29482pt;width:10.2px; id=M5 height=13.425 version=1.1 viewBox=0 0 10.2 13.425 width=10.2 xmlns=http://www.w3.org/2000/svg> <g transform=matrix(1.25,0,0,-1.25,0,13.425)> <g transform=translate(72,-61.26)> <text transform=matrix(1,0,0,-1,-71.95,63.6)> <tspan style=font-size: 12.50px; x=0 y=0>𝜙</tspan> </text> </g> </g> </svg>, <i >&#x3b3;</i><svg style=vertical-align:-0.13794pt;width:7.9875002px; id=M6 height=10.7375 version=1.1 viewBox=0 0 7.9875002 10.7375 width=7.9875002 xmlns=http://www.w3.org/2000/svg> <g transform=matrix(1.25,0,0,-1.25,0,10.7375)> <g transform=translate(72,-63.41)> <text transform=matrix(1,0,0,-1,-71.95,63.6)> <tspan style=font-size: 12.50px; x=0 y=0>𝛿</tspan> </text> </g> </g> </svg> T cells, and neutrophils has been found to be involved in augmented TNF<svg style=vertical-align:-0.1254pt;width:8.9375px; id=M7 height=7.1750002 version=1.1 viewBox=0 0 8.9375 7.1750002 width=8.9375 xmlns=http://www.w3.org/2000/svg> <g transform=matrix(1.25,0,0,-1.25,0,7.175)> <g transform=translate(72,-66.26)> <text transform=matrix(1,0,0,-1,-71.95,66.44)> <tspan style=font-size: 12.50px; x=0 y=0>𝛼</tspan> </text> </g> </g> </svg> expression and production during infection. The recent finding in experimental studies that alternatively activated macrophages (M<svg style=vertical-align:-2.29482pt;width:10.2px; id=M8 height=13.425 version=1.1 viewBox=0 0 10.2 13.425 width=10.2 xmlns=http://www.w3.org/2000/svg> <g transform=matrix(1.25,0,0,-1.25,0,13.425)> <g transform=translate(72,-61.26)> <text transform=matrix(1,0,0,-1,-71.95,63.6)> <tspan style=font-size: 12.50px; x=0 y=0>𝜙</tspan> </text> </g> </g> </svg>2) increase by proliferation rather than recruitment may have significant implications for the understanding and treatment of chronic inflammatory conditions such as encapsulating peritoneal sclerosis (EPS)." @default.
• W2073207703 created "2016-06-24" @default.
• W2073207703 creator A5080592772 @default.
• W2073207703 date "2012-01-01" @default.
• W2073207703 modified "2023-09-25" @default.
• W2073207703 title "The Local Inflammatory Responses to Infection of the Peritoneal Cavity in Humans: Their Regulation by Cytokines, Macrophages, and Other Leukocytes" @default.
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• W2073207703 doi "https://doi.org/10.1155/2012/976241" @default.
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