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• W2073207791 abstract "This prospective trial was opened by the Radiation Therapy Oncology Group (RTOG) in 1998 to evaluate the effectiveness of transrectal ultrasound guided permanent implantation of the prostate compared to historical data of prostatectomy or external beam radiotherapy within a cooperative group setting with special attention to the quality assurance standards of brachytherapy. One hundred and one patients were accrued to this protocol, which closed in April 2000. Accrued patients had low risk prostate cancer (T1-2, GS<6, PSA <10) and underwent an I125 permanent implantation of the prostate (145 Gy TG-43). Of 101 patients, 97 are eligible and analyzable. Of the eligible patients, 96 had brachytherapy data and 95 had adequate follow up for evaluation. Median follow up was 41 months (range 4.5 months to 60.1 months). Ninety-four of the eligible patients had an implant that was delivered either per protocol or with an acceptable minor variation. The 3-year cumulative incidence rate of any failure is 9.8% per the protocol definition of failure (two consecutive rises above the nadir with the rise in PSA exceeding 1 ng/ml above the nadir or positive biopsy). The 3-year biochemical failure rates using the protocol definition and the ASTRO definition were 4.3% and 3.2% respectively. Acute grade 3 or higher toxicity was seen in eight patients, four of the eight were GU toxicity, 2 sexual, and the others hemorrhage. There were no grade 4 or grade 5 acute toxicities. Fifty patients experienced grade 2 toxicity, 44 of the 50 were genitourinary toxicities. Late grade 3 or higher toxicity was noted in 2 patients with grade 3 toxicity both genitourinary and no grade 4 or grade 5 toxicity. This prospective multi-institutional brachytherapy trial was completed successfully with acceptable quality assurance and early results comparable with single institution series. The toxicities are consistent with other reported series. With this trial, the RTOG has demonstrated its capacity to perform a prospective quality assured prostate brachytherapy trial and provides a positive outlook for the feasibility of subsequent cooperative group trials, including the active Phase III trial RTOG P-0232 examining the role of supplemental external beam radiotherapy for prostate brachytherapy" @default.
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• W2073207791 date "2004-09-01" @default.
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• W2073207791 title "Results of a prospective multi-institutional phase II trial (RTOG 98–05) of transrectal ultrasound guided permanent radioactive implantation of the prostate for definitive management of localized adenocarcinoma of the prostate" @default.
• W2073207791 doi "https://doi.org/10.1016/j.ijrobp.2004.06.116" @default.
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