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- W2073207819 abstract "Objective A systematic genome survey was initiated to identify loci that affect the likelihood of reaching age 90 with preserved cognition (successful aging). Methods The genome survey was conducted at 10-cM resolution for simple sequence tandem repeat polymorphisms (SSTRPs) that identify genes for Successful AGing (SAG loci) by virtue of linkage disequilibrium. Efficiency was enhanced by genotyping pools of DNA from 100 cognitively intact elders and 100 young (18–25 years) adults. The comparison groups included equal numbers of white men and women of similar ethnicity that were recruited from the southwestern Pennsylvania region. Results Our genome survey identified nine SAG candidate loci that may influence the likelihood of reaching age 90 or more with preserved cognition. Two of the autosomal SAG loci revealed stronger allelic associations with successful aging in men than women (D1S1728, D8S264) and two were located on sex chromosomes (DXS9902, DYS390). DXS9902 resides within a predicted gene, whereas six of the SAG loci are located within regions previously reported to show linkage to other phenotypes. Conclusions The results of our study suggest that loci with differential effects on the successful aging of men and women may be common. The majority of the SAG candidate loci detected in this study overlap with regions previously reported to show linkage to susceptibility genes for cardiovascular disorders, psychiatric disorders, and the accumulation of tissue damage resulting from oxidative stress. A systematic genome survey was initiated to identify loci that affect the likelihood of reaching age 90 with preserved cognition (successful aging). The genome survey was conducted at 10-cM resolution for simple sequence tandem repeat polymorphisms (SSTRPs) that identify genes for Successful AGing (SAG loci) by virtue of linkage disequilibrium. Efficiency was enhanced by genotyping pools of DNA from 100 cognitively intact elders and 100 young (18–25 years) adults. The comparison groups included equal numbers of white men and women of similar ethnicity that were recruited from the southwestern Pennsylvania region. Our genome survey identified nine SAG candidate loci that may influence the likelihood of reaching age 90 or more with preserved cognition. Two of the autosomal SAG loci revealed stronger allelic associations with successful aging in men than women (D1S1728, D8S264) and two were located on sex chromosomes (DXS9902, DYS390). DXS9902 resides within a predicted gene, whereas six of the SAG loci are located within regions previously reported to show linkage to other phenotypes. The results of our study suggest that loci with differential effects on the successful aging of men and women may be common. The majority of the SAG candidate loci detected in this study overlap with regions previously reported to show linkage to susceptibility genes for cardiovascular disorders, psychiatric disorders, and the accumulation of tissue damage resulting from oxidative stress." @default.
- W2073207819 created "2016-06-24" @default.
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- W2073207819 date "2007-03-01" @default.
- W2073207819 modified "2023-09-26" @default.
- W2073207819 title "Genome Survey for Loci That Influence Successful Aging: Results at 10-cM Resolution" @default.
- W2073207819 cites W1545695267 @default.
- W2073207819 cites W1551600243 @default.
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- W2073207819 cites W16868002 @default.
- W2073207819 cites W1847168837 @default.
- W2073207819 cites W1973075403 @default.
- W2073207819 cites W1973754944 @default.
- W2073207819 cites W1975646059 @default.
- W2073207819 cites W1981430379 @default.
- W2073207819 cites W1985288864 @default.
- W2073207819 cites W1994127362 @default.
- W2073207819 cites W1994639562 @default.
- W2073207819 cites W1998290897 @default.
- W2073207819 cites W1999631936 @default.
- W2073207819 cites W2000896555 @default.
- W2073207819 cites W2009168425 @default.
- W2073207819 cites W2009285220 @default.
- W2073207819 cites W2011862126 @default.
- W2073207819 cites W2015154913 @default.
- W2073207819 cites W2027346167 @default.
- W2073207819 cites W2031514882 @default.
- W2073207819 cites W2033564025 @default.
- W2073207819 cites W2039376593 @default.
- W2073207819 cites W2047432476 @default.
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- W2073207819 cites W2052958766 @default.
- W2073207819 cites W2063132928 @default.
- W2073207819 cites W2063489874 @default.
- W2073207819 cites W2066276433 @default.
- W2073207819 cites W2068134262 @default.
- W2073207819 cites W2069863984 @default.
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- W2073207819 cites W2097504226 @default.
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- W2073207819 cites W2103268140 @default.
- W2073207819 cites W2108791364 @default.
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- W2073207819 cites W2311501921 @default.
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- W2073207819 doi "https://doi.org/10.1097/01.jgp.0000231681.89741.af" @default.
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