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- W2073208030 abstract "We compared the intracellular survival and growth of Legionella pneumophila Philadelphia-1 in peritoneal macrophages obtained from A/J, C57BL/6, and X-linked chronic granulomatous disease (CGD) mice produced from C57BL/6 strain. The initial killing was observed in A/J and C57BL/6 macrophages at 2, 4 and 6 hr after in vitro phagocytosis, but not in the CGD macrophages. Thereafter, there was a 10-fold increase of CFU in A/J macrophages. The bacteria, however, did not proliferate in C57BL/6 and CGD macrophages at 24 or 48 hr after in vitro phagocytosis. These results suggest that effector molecules for the initial killing are a superoxide anion and its metabolites, and Lgn1 gene product inhibits the intracellular growth of L. pneumophila independently of NADPH oxidase." @default.
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- W2073208030 date "2001-07-01" @default.
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- W2073208030 title "Fate ofLegionella pneumophilain Macrophages of C57BL/6 Chronic Granulomatous Disease Mice" @default.
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- W2073208030 doi "https://doi.org/10.1111/j.1348-0421.2001.tb02655.x" @default.
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