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- W2073208045 abstract "To evaluate the efficacy of proton beam therapy as definitive treatment for localized hepatocellular carcinoma. Between June 1992 and December 2005, one hundred fourteen patients with localized hepatocellular carcinoma were initially treated with proton beam therapy (PBT) alone. Ninety-six patients (84%) had hepatitis virus infection. The diameter of the tumor ranged from 10 to 135 mm (median: 41.2 mm). Nine patients had portal vein tumor thrombus (Vp2/ 3/ 4 = 3/ 2/ 4). Basically, three treatment protocols (66 GyE in 10 fractions; 72.6 GyE in 22 fractions; 77 GyE in 35 fractions) were applied, depending on tumor location. After median follow-up period of 37.3 months (2.3 to 155.3 months), 61 patients were alive and 53 were dead. Overall survival rate (OS) for all the patients was 75.9% at 3 years and 48.5% at 5 years. OS at 3 years by liver function were 82.7%, 70.8%, and 25% for Child A, B, and C cases, respectively. Progression-free survival was 42.3% at 3 years for all the patients, although local progression was observed in 10.3% of the treated tumor. Treatment related morbidity was minimal. These results suggest PBT can play a role of definitive treatment of patients with localized hepatocellular carcinoma." @default.
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- W2073208045 date "2013-10-01" @default.
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- W2073208045 title "Long-term Survival in Patients With Hepatocellular Carcinoma Initially Treated With Definitive Proton Beam Therapy" @default.
- W2073208045 doi "https://doi.org/10.1016/j.ijrobp.2013.06.845" @default.
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