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- W2073214708 abstract "Cancer chemotherapy-induced neuropathy (CIN) is a common neurologic complication of cancer treatment. Because no effective preventative or treatment strategies are available for CIN, it can result in delays or cessation of chemotherapy. Patients with CIN can experience pain, decreased functional status, and poorer quality of life that can persist after the completion of chemotherapy. The subjective and objective characteristics of CIN remain unknown. As part of a larger cross-sectional, descriptive study, the purpose of this study was to evaluate for differences in pain characteristics in the hands and feet of patients who had CIN in both extremities. A cohort of 154 patients who had completed chemotherapy and self-reported CIN in their hands and feet were evaluated with a detailed questionnaire about pain characteristics (i.e., intensity, qualities, and interference with function). Compared to their hands, patients rated pain in their feet as significantly worse on intensity (p<.0001) and duration (p=.005). Pain interference scores for general activity, mood, walking ability, relations with others, sleep, and enjoyment of life were significantly higher in the feet (all p<.0001). For all of the qualities on the Pain Qualities Assessment Scale, ratings were significantly higher for the feet (i.e., intense, sharp, hot, dull, cold, sensitive, shooting, numb, electrical, tingling, cramping, heavy, unpleasant (all p < .001), tender (p=.032), itchy (p=.037), radiating (p=.003), throbbing (p=.004), and aching (p=.015)). Results from this study provide a detailed characterization of self-reported pain characteristics associated with chronic CIN, and striking differences between the differential severity of characteristics in the feet versus the hands. Additionally, these results suggest CIN is associated with decrements in functional status and mood. Findings from this study support the need for further research that evaluates subjective and objective characteristics of CIN that can be used to guide the development of future intervention studies." @default.
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- W2073214708 date "2015-04-01" @default.
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- W2073214708 title "(119) Characterization of chemotherapy-induced neuropathy using patient reported outcome measures" @default.
- W2073214708 doi "https://doi.org/10.1016/j.jpain.2015.01.033" @default.
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